Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
about
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation updateBiochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimersLRRK2 and the stress response: interaction with MKKs and JNK-interacting proteinsARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2Insight into the mode of action of the LRRK2 Y1699C pathogenic mutantGTP binding controls complex formation by the human ROCO protein MASL1GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signallingThe Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sitesMutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathwaysParkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domainActivation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's DiseaseCurrent understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor designHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsKissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopyAtomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic 2-microglobulin variantStructural Basis of Outer Membrane Protein Biogenesis in BacteriaRoco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutationsRevisiting the Roco G-protein cycleStructural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contactsProtective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.A phylogenetic survey of myotubularin genes of eukaryotes: distribution, protein structure, evolution, and gene expressionThe WD40 domain is required for LRRK2 neurotoxicity.The R1441C mutation alters the folding properties of the ROC domain of LRRK2.Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's diseaseArsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistributionLRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.Role of LRRK2 kinase dysfunction in Parkinson diseaseInterplay between HIV entry and transportin-SR2 dependencyModels for LRRK2-Linked Parkinsonism.Evolution and diversity of the Ras superfamily of small GTPases in prokaryotesLRRK2 Parkinson disease mutations enhance its microtubule association.Highly dynamic exon shuffling in candidate pathogen receptors ... what if brown algae were capable of adaptive immunity?Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase ActivityMechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.LRRK2 autophosphorylation enhances its GTPase activityLRRK2: an éminence grise of Wnt-mediated neurogenesis?Structure, function, and leucine-rich repeat kinase 2: On the importance of reproducibility in understanding Parkinson's disease.Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.LRRK2 in Parkinson's disease: in vivo models and approaches for understanding pathogenic roles.LRRK2: cause, risk, and mechanism.
P2860
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P2860
Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structure of the Roc–COR domai ...... e human LRRK2 Parkinson kinase
@ast
Structure of the Roc–COR domai ...... e human LRRK2 Parkinson kinase
@en
Structure of the Roc–COR domai ...... e human LRRK2 Parkinson kinase
@nl
type
label
Structure of the Roc–COR domai ...... e human LRRK2 Parkinson kinase
@ast
Structure of the Roc–COR domai ...... e human LRRK2 Parkinson kinase
@en
Structure of the Roc–COR domai ...... e human LRRK2 Parkinson kinase
@nl
prefLabel
Structure of the Roc–COR domai ...... e human LRRK2 Parkinson kinase
@ast
Structure of the Roc–COR domai ...... e human LRRK2 Parkinson kinase
@en
Structure of the Roc–COR domai ...... e human LRRK2 Parkinson kinase
@nl
P2093
P2860
P3181
P356
P1433
P1476
Structure of the Roc–COR domai ...... e human LRRK2 Parkinson kinase
@en
P2093
Arjan Kortholt
Katja Gotthardt
Peter J M Van Haastert
P2860
P304
P3181
P356
10.1038/EMBOJ.2008.150
P407
P577
2008-08-20T00:00:00Z