about
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1G2385R and I2020T Mutations Increase LRRK2 GTPase ActivityLeucine-rich repeat kinase 2 and Parkinson's disease.Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.LRRK2 and the Immune System.LRRK2 Regulates Voltage-Gated Calcium Channel FunctionIdentification of bona-fide LRRK2 kinase substrates.A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.The LRRK2 signalling system.LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease.Molecular Insights and Functional Implication of LRRK2 Dimerization.LRRK2 Phosphorylation.The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro.
P2860
Q28822211-A6DF7210-2C69-4BD9-A404-C9A8E750B248Q29347540-33A82F03-2269-44E5-B69B-3BDC695E0B3BQ38977031-2B45A3FA-89E8-44ED-B54D-763BDAD313B0Q39137358-C7B812E3-6B5D-4A95-97EC-E4BB0708FE8BQ39206431-3D1D69BA-FADB-4952-BBED-53E439EEB4CCQ39206438-1F4438ED-94F1-43E8-AC15-21A26B8BE59FQ42001785-DFB33E66-2F5D-498F-8E98-A8413580BE56Q42363197-6E585874-8C8D-4181-9E9A-E11E1DBE0B92Q47127108-FCF39215-4629-45F3-846C-0E1DA4DE61ECQ47222316-C03CD40E-6956-45FC-98CD-E9B24F5FC59CQ47225650-1E45EF8B-16B4-49B0-8770-40604CC38A09Q47362838-7708385F-468A-4E50-B7EB-8A197C7E7CA6Q48003270-A1BCF5E9-2A4F-4066-8F70-CC5C433734C4Q51082151-A159B939-5536-4B77-AAEF-83724BBC0FD9Q51082156-D4B800F9-E588-4CFD-89BD-CBE1CF8B065EQ51275277-2D12370A-645C-45BD-8928-CF4644D26173
P2860
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
LRRK2 autophosphorylation enhances its GTPase activity
@ast
LRRK2 autophosphorylation enhances its GTPase activity
@en
type
label
LRRK2 autophosphorylation enhances its GTPase activity
@ast
LRRK2 autophosphorylation enhances its GTPase activity
@en
prefLabel
LRRK2 autophosphorylation enhances its GTPase activity
@ast
LRRK2 autophosphorylation enhances its GTPase activity
@en
P2093
P2860
P356
P1433
P1476
LRRK2 autophosphorylation enhances its GTPase activity
@en
P2093
James A Mobley
Lawrence J DeLucas
Richard A Kahn
Zhiyong Liu
P2860
P304
P356
10.1096/FJ.15-277095
P407
P577
2015-09-22T00:00:00Z