ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
about
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)LRRK2 transport is regulated by its novel interacting partner Rab32ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyLRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsNo dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblastsRevisiting the Roco G-protein cycleA visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955.LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease.Contribution of GTPase activity to LRRK2-associated Parkinson diseaseMechanisms of LRRK2-mediated neurodegeneration.Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease.The GTPase function of LRRK2.Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).Genetic, structural, and molecular insights into the function of ras of complex proteins domains.LRRK2 pathobiology in Parkinson's disease.Cellular processes associated with LRRK2 function and dysfunctionLRRK2 Pathways Leading to Neurodegeneration.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.LRRK2 Phosphorylation.LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson's disease: a review.
P2860
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P248
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P2860
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
description
2010 nî lūn-bûn
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2010 թուականին հրատարակուած գիտական յօդուած
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2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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name
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@ast
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@en
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@en-gb
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@nl
type
label
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@ast
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@en
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@en-gb
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@nl
prefLabel
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@ast
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@en
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@en-gb
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@nl
P2093
P2860
P50
P921
P1433
P1476
ARHGEF7 (Beta-PIX) acts as gua ...... r leucine-rich repeat kinase 2
@en
P2093
Frank Gillardon
Karina Haebig
Marta Garcia Miralles
Michael Bonin
Saskia Biskup
P2860
P304
P356
10.1371/JOURNAL.PONE.0013762
P407
P577
2010-01-01T00:00:00Z