Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A - Wikidata - awgldk - TriplyDB

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A

http://www.wikidata.org/entity/Q27653526

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Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected Erythrocytes Structural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during Pregnancy Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition Structural Basis for the ABO Blood-Group Dependence of Plasmodium falciparum Rosetting Molecular Basis for Sialic Acid-dependent Receptor Recognition by the Plasmodium falciparum Invasion Protein Erythrocyte-binding Antigen-140/BAEBL Structural analysis of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for Plasmodium vivax malaria vaccine design IgM, Fc mu Rs, and malarial immune evasion Antigen reversal identifies targets of opsonizing IgGs against pregnancy-associated malaria Plasmodium vivax adherence to placental glycosaminoglycans.Plasmodium vivax tryptophan-rich antigen PvTRAg33.5 contains alpha helical structure and multidomain architecture.Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women.Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes.Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region.Exploiting enzyme specificities in digestions of chondroitin sulfates A and C: production of well-defined hexasaccharides Sequence polymorphism, segmental recombination and toggling amino acid residues within the DBL3X domain of the VAR2CSA placental malaria antigen.The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains Insect cells are superior to Escherichia coli in producing malaria proteins inducing IgG targeting PfEMP1 on infected erythrocytes Designing a VAR2CSA-based vaccine to prevent placental malaria.In silico studies on DARC.Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins.Structure-function-immunogenicity studies of PfEMP1 domain DBL2βPF11_0521, a malaria parasite ligand for ICAM-1.Cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced.VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placenta Using the PfEMP1 head structure binding motif to deal a blow at severe malaria.How specific is Plasmodium falciparum adherence to chondroitin 4-sulfate?Parity-dependent recognition of DBL1X-3X suggests an important role of the VAR2CSA high-affinity CSA-binding region in the development of the humoral response against placental malaria.Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response to Plasmodium falciparum VAR2CSA-Expressing Parasites.High levels of antibodies to multiple domains and strains of VAR2CSA correlate with the absence of placental malaria in Cameroonian women living in an area of high Plasmodium falciparum transmission.Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay The Vaccinia Virus H3 Envelope Protein, a Major Target of Neutralizing Antibodies, Exhibits a Glycosyltransferase Fold and Binds UDP-Glucose Structural interactions in chondroitin 4-sulfate mediated adherence of Plasmodium falciparum infected erythrocytes in human placenta during pregnancy-associated malaria.Sulfation and cation effects on the conformational properties of the glycan backbone of chondroitin sulfate disaccharides Structural insights into chondroitin sulphate A binding Duffy-binding-like domains from Plasmodium falciparum: implications for intervention strategies against placental malaria.Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris.Glycosaminoglycans in infectious disease.Developing vaccines to prevent malaria in pregnant women.

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P2860

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A

http://www.wikidata.org/entity/Q27653526

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2008 nî lūn-bûn

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2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Structure of the DBL3x domain ...... xed with chondroitin sulfate A

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Structure of the DBL3x domain ...... xed with chondroitin sulfate A

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Structure of the DBL3x domain ...... xed with chondroitin sulfate A

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Structure of the DBL3x domain ...... xed with chondroitin sulfate A

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Structure of the DBL3x domain ...... xed with chondroitin sulfate A

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Structure of the DBL3x domain ...... xed with chondroitin sulfate A

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Structure of the DBL3x domain ...... xed with chondroitin sulfate A

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Structure of the DBL3x domain ...... xed with chondroitin sulfate A

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Structure of the DBL3x domain ...... xed with chondroitin sulfate A

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Nature Structural & Molecular Biology

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Structure of the DBL3x domain ...... xed with chondroitin sulfate A

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Apostolos G Gittis

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D Channe Gowda

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David N Garboczi

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Kavita Singh

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Phuc Nguyen

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P2860

Heparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal Domain

The Structure of a Chondroitin Sulfate-binding Domain Important in Placental Malaria

Chondroitin 4-sulfate: the structure of a sulfated glycosaminoglycan

Version 1.2 of the Crystallography and NMR system

Phasercrystallographic software

The CCP4 suite: programs for protein crystallography

Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria

The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytes

Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes

Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes

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10.1038/NSMB.1479

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9

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15

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Louis H. Miller

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2008-09-01T00:00:00Z

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23951873

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1016614248

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19172746

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pregnancy-associated malaria

protein structure

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2658892

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