Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
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Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpartThe role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammationInhibition of human peptide deformylase disrupts mitochondrial functionOverexpression of peptide deformylase in breast, colon, and lung cancers.Genome-wide identification and in silico analysis of poplar peptide deformylases.Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer.A unique peptide deformylase platform to rationally design and challenge novel active compounds.Peptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery.Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers.Metalloproteomics, metalloproteomes, and the annotation of metalloproteins.Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase.The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation.Successful COG8 and PDF overlap is mediated by alterations in splicing and polyadenylation signals.Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites.
P2860
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P2860
Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
@ast
Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
@en
Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
@nl
type
label
Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
@ast
Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
@en
Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
@nl
prefLabel
Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
@ast
Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
@en
Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
@nl
P2093
P2860
P3181
P1476
Structure and activity of human mitochondrial peptide deformylase, a novel cancer target
@en
P2093
David A Scheinberg
Guangli Yang
Yehuda Goldgur
Yueming Li
P2860
P304
P3181
P356
10.1016/J.JMB.2009.02.032
P407
P577
2009-02-21T00:00:00Z