Structural and mechanistic insights into the association of PKC -C2 domain to PtdIns(4,5)P2 - Wikidata - awgldk - TriplyDB

Structural and mechanistic insights into the association of PKC -C2 domain to PtdIns(4,5)P2

Structural and mechanistic insights into the association of PKC -C2 domain to PtdIns(4,5)P2

http://www.wikidata.org/entity/Q27654558

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IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes Oscillations in the lateral pressure of lipid monolayers induced by nonlinear chemical dynamics of the second messengers MARCKS and protein kinase C Membrane Binding and Modulation of the PDZ Domain of PICK1 Dynamics and Membrane Interactions of Protein Kinase C RAB-10 Promotes EHBP-1 Bridging of Filamentous Actin and Tubular Recycling Endosomes.Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)Crystal Structure and Allosteric Activation of Protein Kinase C βII Pb 2+ as Modulator of Protein–Membrane Interactions Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1 Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment Notch ligand delta-like1: X-ray crystal structure and binding affinity Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together.Characterization of the lipid binding properties of Otoferlin reveals specific interactions between PI(4,5)P2 and the C2C and C2F domains.Putting the pH into phosphatidic acid signaling Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity.Phosphatidylinositol-4,5-bisphosphate enhances anionic lipid demixing by the C2 domain of PKCα Lipid targeting domain with dual-membrane specificity that expands the diversity of intracellular targeting reactions.Cellular and molecular interactions of phosphoinositides and peripheral proteins Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1.Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: a combined molecular dynamics and experimental study.Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα.Allosteric properties of PH domains in Arf regulatory proteins.Membrane-surface anchoring of charged diacylglycerol-lactones correlates with biological activities Conditional peripheral membrane proteins: facing up to limited specificity.Role of calcium in membrane interactions by PI(4,5)P₂-binding proteins.Structural characterization of the Rabphilin-3A-SNAP25 interaction.Classical protein kinases C are regulated by concerted interaction with lipids: the importance of phosphatidylinositol-4,5-bisphosphate.Structural insights into the interactions of phorbol ester and bryostatin complexed with protein kinase C: a comparative molecular dynamics simulation study.Intramolecular conformational changes optimize protein kinase C signaling.Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII.Functional Characterization of the N-Terminal C2 Domain from Arabidopsis thaliana Phospholipase Dα and Dβ.Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin- and PI3-kinase-dependent, but Akt-independent, internalisation event C2-domain abscisic acid-related proteins mediate the interaction of PYR/PYL/RCAR abscisic acid receptors with the plasma membrane and regulate abscisic acid sensitivity in Arabidopsis.

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P2860

Structural and mechanistic insights into the association of PKC -C2 domain to PtdIns(4,5)P2

http://www.wikidata.org/entity/Q27654558

description

2009 nî lūn-bûn

@nan

2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2009 թվականի ապրիլին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Structural and mechanistic ins ...... KC -C2 domain to PtdIns(4,5)P2

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Structural and mechanistic ins ...... KC -C2 domain to PtdIns(4,5)P2

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Structural and mechanistic ins ...... KC -C2 domain to PtdIns(4,5)P2

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Structural and mechanistic ins ...... KC -C2 domain to PtdIns(4,5)P2

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Structural and mechanistic ins ...... KC -C2 domain to PtdIns(4,5)P2

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Structural and mechanistic ins ...... KC -C2 domain to PtdIns(4,5)P2

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prefLabel

Structural and mechanistic ins ...... KC -C2 domain to PtdIns(4,5)P2

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Structural and mechanistic ins ...... KC -C2 domain to PtdIns(4,5)P2

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Structural and mechanistic ins ...... KC -C2 domain to PtdIns(4,5)P2

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Proceedings of the National Academy of Sciences of the United States of America

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Structural and mechanistic ins ...... KC -C2 domain to PtdIns(4,5)P2

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Consuelo Marin-Vicente

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Cristina Ferrer-Orta

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Jordi Querol-Audí

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Juan C Gómez-Fernández

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Marta Guerrero-Valero

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Senena Corbalán-García

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P2860

Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+

Phosphoinositides in cell regulation and membrane dynamics

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells

The ATP-dependent membrane localization of protein kinase Calpha is regulated by Ca2+ influx and phosphatidylinositol 4,5-bisphosphate in differentiated PC12 cells.

C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

Surprising similarities in structure comparison

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Nuria Verdaguer

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