Crystal structure of autotaxin and insight into GPCR activation by lipid mediators - Wikidata - awgldk - TriplyDB

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6 Regulation of T cell motility in vitro and in vivo by LPA and LPA2 Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling Structural basis for specific inhibition of Autotaxin by a DNA aptamer Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling Autotaxin: structure-function and signaling Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life TP Atlas: integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration.Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif.Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response Cellular function and molecular structure of ecto-nucleotidases.Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7.Lysophosphatidic acid in atherosclerotic diseases An LPA species (18:1 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model.Non-invasive imaging of tumors by monitoring autotaxin activity using an enzyme-activated near-infrared fluorogenic substrate.Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells.Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.Ligand-based autotaxin pharmacophore models reflect structure-based docking results.Phospholipase D: enzymology, functionality, and chemical modulation Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycle.Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish.Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1 The autotaxin-lysophosphatidic acid-lysophosphatidic acid receptor cascade: proposal of a novel potential therapeutic target for treating glioblastoma multiforme Chemical evolution of autotaxin inhibitors Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma.Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility.Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase

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P2860

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

http://www.wikidata.org/entity/Q27666524

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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name

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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prefLabel

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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Nature Structural & Molecular Biology

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Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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Asuka Inoue

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Emiko Mihara

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Hiroshi Nishimasu

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Junichi Takagi

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Kotaro Hama

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Shinichi Okudaira

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205-12

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scholarly article

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2322583

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10.1038/NSMB.1998

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2

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18

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Ryuichiro Ishitani

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2011-02-01T00:00:00Z

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1041997817

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21240269

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G protein-coupled receptor

crystal structure