The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition

The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition

Item
http://www.wikidata.org/entity/Q27733363
Mechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticityFlexible ligand docking using conformational ensemblesRole of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: Calorimetric and crystallographic analysis of the K48Q mutantDesign, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitorsDevelopment and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targetsCrystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity.Thymidylate synthase inhibition: a structure-based rationale for drug design.Docking molecules by families to increase the diversity of hits in database screens: computational strategy and experimental evaluation.Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.
P2860

The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition

Item
http://www.wikidata.org/entity/Q27733363
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1996年の論文
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1996年論文
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1996年論文
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1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
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name
The complex of the anti-cancer ...... s for a new mode of inhibition
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The complex of the anti-cancer ...... s for a new mode of inhibition
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The complex of the anti-cancer ...... s for a new mode of inhibition
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type
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The complex of the anti-cancer ...... s for a new mode of inhibition
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The complex of the anti-cancer ...... s for a new mode of inhibition
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The complex of the anti-cancer ...... s for a new mode of inhibition
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prefLabel
The complex of the anti-cancer ...... s for a new mode of inhibition
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The complex of the anti-cancer ...... s for a new mode of inhibition
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The complex of the anti-cancer ...... s for a new mode of inhibition
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The complex of the anti-cancer ...... s for a new mode of inhibition
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10.1016/S0969-2126(96)00010-X
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