Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy - Wikidata - awgldk - TriplyDB

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

http://www.wikidata.org/entity/Q27673508

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Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells Targeting Cancer Metabolism - Revisiting the Warburg Effects Novel drugs that target the metabolic reprogramming in renal cell cancer Pyruvate Kinase M2: A Potential Target for Regulating Inflammation Dysregulated metabolism contributes to oncogenesis Pyruvate kinase: Function, regulation and role in cancer Serine, glycine and one-carbon units: cancer metabolism in full circle Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review Fueling immunity: insights into metabolism and lymphocyte function Free Glycine Accelerates the Autoproteolytic Activation of Human Asparaginase ROS homeostasis and metabolism: a critical liaison for cancer therapy PCK2 activation mediates an adaptive response to glucose depletion in lung cancer Expanded cellular amino acid pools containing phosphoserine, phosphothreonine, and phosphotyrosine Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability In silico investigation of potential pyruvate kinase M2 regulators from traditional Chinese medicine against cancers.The Warburg effect: evolving interpretations of an established concept Activators of PKM2 in cancer metabolism.Structural insight into mechanisms for dynamic regulation of PKM2.A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.L-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation.Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth.PKM2 and cancer: The function of PKM2 beyond glycolysis.Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma.Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator.The importance of serine metabolism in cancer Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth.Stress eating and tuning out: cancer cells re-wire metabolism to counter stress.Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted delivery.The Role of Pyruvate Kinase M2 in Cancer Metabolism.AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma.Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.Lack of Evidence for PKM2 Protein Kinase Activity.Altered metabolite levels in cancer: implications for tumour biology and cancer therapy.PKM2, cancer metabolism, and the road ahead.Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.PKM2, a Central Point of Regulation in Cancer Metabolism.

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P2860

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

http://www.wikidata.org/entity/Q27673508

description

2012 nî lūn-bûn

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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年论文

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name

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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J.CHEMBIOL.2012.07.021

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Chemistry and Biology

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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Byron DeLaBarre

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Charles Kung

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Cheng Fang

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Ed Driggers

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Erin Murphy

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Fan Jiang

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Francesco G Salituro

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Giovanni Cianchetta

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Hin Koon Woo

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Hua Yang

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P2860

Bioconductor: open software development for computational biology and bioinformatics

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion

Pyruvate kinase M2 is a phosphotyrosine-binding protein

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

Pegaspargase: a review of clinical studies

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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