about
Novel drugs that target the metabolic reprogramming in renal cell cancerPyruvate Kinase M2: A Potential Target for Regulating InflammationMitochondria in Cancer Energy Metabolism: Culprits or Bystanders?Pyruvate kinase: Function, regulation and role in cancerUndercover: gene control by metabolites and metabolic enzymesPyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway.Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.Chromatin-bound MDM2, a new player in metabolism.The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina.AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth.The Role of Pyruvate Kinase M2 in Cancer Metabolism.PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells.PKM2, cancer metabolism, and the road ahead.PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2PGK1 is a new member of the protein kinomeGlucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.PKM2 is not required for colon cancer initiated by APC loss.PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.Metabolic Kinases Moonlighting as Protein Kinases.Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling.Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN.Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma.PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis.Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways.Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repairPKM2 is not required for pancreatic ductal adenocarcinoma
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description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Lack of Evidence for PKM2 Protein Kinase Activity.
@en
type
label
Lack of Evidence for PKM2 Protein Kinase Activity.
@en
prefLabel
Lack of Evidence for PKM2 Protein Kinase Activity.
@en
P2093
P2860
P1433
P1476
Lack of Evidence for PKM2 Protein Kinase Activity.
@en
P2093
Aaron M Hosios
Brian P Fiske
Matthew G Vander Heiden
P2860
P304
P356
10.1016/J.MOLCEL.2015.07.013
P577
2015-08-19T00:00:00Z