Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein
about
Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in DiseaseDNA methylation pathways and their crosstalk with histone methylationPartners in crime: The role of tandem modules in gene transcriptionConserved linker regions and their regulation determine multiple chromatin-binding modes of UHRF1Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functionsHistone-binding domains: strategies for discovery and characterization.Topoisomerase II regulates the maintenance of DNA methylation.Frequent SOCS3 and 3OST2 promoter methylation and their epigenetic regulation in endometrial carcinoma.DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryosAn Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1.A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choiceHemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition.Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation.Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).Readout of epigenetic modifications.Tudor: a versatile family of histone methylation 'readers'.Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks.Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks.PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311.DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitinationGenetic Studies on Mammalian DNA Methyltransferases.Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery.The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism.DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation.Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability.Characteristics of a PHD Finger Subtype.UHRF1 epigenetically down-regulates UbcH8 to inhibit apoptosis in cervical cancer cells.An Intramolecular Interaction of UHRF1 Reveals Dual Control for Its Histone Association.UHRF1 binds chromatin with hemimethylated cytosineStructural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation.Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger-containing 1 (UHRF1) for anti-cancer drug development.Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a.
P2860
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P2860
Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structural Insight into Coordi ...... ING Finger Domains, 1) Protein
@ast
Structural Insight into Coordi ...... ING Finger Domains, 1) Protein
@en
Structural Insight into Coordi ...... ING Finger Domains, 1) Protein
@nl
type
label
Structural Insight into Coordi ...... ING Finger Domains, 1) Protein
@ast
Structural Insight into Coordi ...... ING Finger Domains, 1) Protein
@en
Structural Insight into Coordi ...... ING Finger Domains, 1) Protein
@nl
prefLabel
Structural Insight into Coordi ...... ING Finger Domains, 1) Protein
@ast
Structural Insight into Coordi ...... ING Finger Domains, 1) Protein
@en
Structural Insight into Coordi ...... ING Finger Domains, 1) Protein
@nl
P2093
P2860
P3181
P356
P1476
Structural Insight into Coordi ...... ING Finger Domains, 1) Protein
@en
P2093
Huirong Yang
Jianxiong Xiao
Jingdong Cheng
Tingting Zhu
P2860
P304
P3181
P356
10.1074/JBC.M112.415398
P407
P577
2013-01-11T00:00:00Z