Structure of the human smoothened receptor bound to an antitumour agent - Wikidata - awgldk - TriplyDB

Structure of the human smoothened receptor bound to an antitumour agent

Structure of the human smoothened receptor bound to an antitumour agent

http://www.wikidata.org/entity/Q27677951

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Structure of class B GPCR corticotropin-releasing factor receptor 1 Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors Structural Studies of G Protein-Coupled Receptors Post-expression strategies for structural investigations of membrane proteins.Large-scale production and protein engineering of G protein-coupled receptors for structural studies Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1 Search for β2 adrenergic receptor ligands by virtual screening via grid computing and investigation of binding modes by docking and molecular dynamics simulations Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain Smoothened variants explain the majority of drug resistance in basal cell carcinoma An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib Generic GPCR residue numbers - aligning topology maps while minding the gaps Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs Structural approaches to understanding retinal proteins needed for vision Conformational states of the full-length glucagon receptor Structural basis of Smoothened regulation by its extracellular domains Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications Sequence, structure and ligand binding evolution of rhodopsin-like G protein-coupled receptors: a crystal structure-based phylogenetic analysis Invited review: GPCR structural characterization: Using fragments as building blocks to determine a complete structure.Cryoprotection of lipid membranes for high-resolution solid-state NMR studies of membrane peptides and proteins at low temperature.Improving homology modeling of G-protein coupled receptors through multiple-template derived conserved inter-residue interactions.The role of experimental and computational structural approaches in 7TM drug discovery.Structure and function of serotonin G protein-coupled receptors.A disorder-to-order structural transition in the COOH-tail of Fz4 determines misfolding of the L501fsX533-Fz4 mutant Smoothened goes molecular: new pieces in the hedgehog signaling puzzle G protein-coupled receptors in cardiac biology: old and new receptors Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand Femtosecond crystallography of membrane proteins in the lipidic cubic phase.

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Structure of the human smoothened receptor bound to an antitumour agent

http://www.wikidata.org/entity/Q27677951

description

2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013 թվականի մայիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Structure of the human smoothened receptor bound to an antitumour agent

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Structure of the human smoothened receptor bound to an antitumour agent

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Structure of the human smoothened receptor bound to an antitumour agent

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type

label

Structure of the human smoothened receptor bound to an antitumour agent

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Structure of the human smoothened receptor bound to an antitumour agent

@en

Structure of the human smoothened receptor bound to an antitumour agent

@nl

prefLabel

Structure of the human smoothened receptor bound to an antitumour agent

@ast

Structure of the human smoothened receptor bound to an antitumour agent

@en

Structure of the human smoothened receptor bound to an antitumour agent

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Structure of the human smoothened receptor bound to an antitumour agent

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Bryan L Roth

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Chong Wang

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Fai Yiu Siu

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Gye Won Han

http://www.w3.org/2001/XMLSchema#string

Wei Liu

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P2860

The Frizzled family: receptors for multiple signal transduction pathways

The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi

Structure of the human κ-opioid receptor in complex with JDTic

Evidence for allosteric interactions of antagonist binding to the smoothened receptor

Activating Smoothened mutations in sporadic basal-cell carcinoma

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

Structural basis of Wnt recognition by Frizzled

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

MolProbity: all-atom structure validation for macromolecular crystallography

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338-43

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scholarly article

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1509165

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10.1038/NATURE12167

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7449

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497

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Vsevolod Katritch

Raymond C Stevens

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2013-05-16T00:00:00Z

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1002424147

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23636324

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3657389

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