NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity
about
Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them allSuppression of APOBEC3-mediated restriction of HIV-1 by VifStructural Insights into HIV-1 Vif-APOBEC3F InteractionStructural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal StructureAPOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcriptsA DNA sequence recognition loop on APOBEC3A controls substrate specificityInteraction of APOBEC3A with DNA assessed by atomic force microscopyCytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization.Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.Toward Closing the Gap: Quantum Mechanical Calculations and Experimentally Measured Chemical Shifts of a Microcrystalline Lectin.Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulationAssociation of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancerClustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitnessHigh-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.Sequence and structural determinants of human APOBEC3H deaminase and anti-HIV-1 activities.A high-resolution 2D J-resolved NMR detection technique for metabolite analyses of biological samples.Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA.APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophagesCatalytic analysis of APOBEC3G involving real-time NMR spectroscopy reveals nucleic acid determinants for deamination.Structure of the Vif-binding domain of the antiviral enzyme APOBEC3GCharacterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine.Transmission electron microscopy for the evaluation and optimization of crystal growthDNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B.Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.Inhibition of APOBEC3G activity impedes double-stranded DNA repairA computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif.The ssDNA Mutator APOBEC3A Is Regulated by Cooperative DimerizationStructural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversificationSingle-Molecule Force Spectroscopy Studies of APOBEC3A-Single-Stranded DNA Complexes.Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity.Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase.Crystal structures of APOBEC3G N-domain alone and its complex with DNA.The topography of mutational processes in breast cancer genomes.A biochemical analysis linking APOBEC3A to disparate HIV-1 restriction and skin cancerThe local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties.Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket.The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions.
P2860
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P2860
NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
NMR structure of human restric ...... binding and enzyme specificity
@ast
NMR structure of human restric ...... binding and enzyme specificity
@en
NMR structure of human restric ...... binding and enzyme specificity
@nl
type
label
NMR structure of human restric ...... binding and enzyme specificity
@ast
NMR structure of human restric ...... binding and enzyme specificity
@en
NMR structure of human restric ...... binding and enzyme specificity
@nl
prefLabel
NMR structure of human restric ...... binding and enzyme specificity
@ast
NMR structure of human restric ...... binding and enzyme specificity
@en
NMR structure of human restric ...... binding and enzyme specificity
@nl
P2093
P2860
P3181
P356
P1476
NMR structure of human restric ...... binding and enzyme specificity
@en
P2093
Chang-Hyeock Byeon
In-Ja L Byeon
Jinwoo Ahn
Jozef Hritz
Judith G Levin
Kamil Hercík
Lisa M Charlton
Mithun Mitra
P2860
P2888
P3181
P356
10.1038/NCOMMS2883
P407
P577
2013-01-01T00:00:00Z
P5875
P6179
1007409494