Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
about
Mechanisms of drug resistance in colon cancer and its therapeutic strategiesMultiple Drug Transport Pathways through Human P-Glycoprotein.Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.Refined structures of mouse P-glycoproteinMultiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)Nanobodies as Probes for Protein Dynamics in Vitro and in Cells.Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporterComputational predictive models for P-glycoprotein inhibition of in-house chalcone derivatives and drug-bank compounds.Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody.Effect of traditional Chinese medicine components on multidrug resistance in tumors mediated by P-glycoprotein.Docking applied to the prediction of the affinity of compounds to P-glycoproteinDirected evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance.Computational Recipe for Efficient Description of Large-Scale Conformational Changes in Biomolecular SystemsStructure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers.A general protocol for the generation of Nanobodies for structural biologyUnderstanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoproteinStructural characterization of two metastable ATP-bound states of P-glycoprotein.Distinct conformational spectrum of homologous multidrug ABC transporters.Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics.In vitro nanobody discovery for integral membrane protein targetsIdentification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA.Three-dimensional structure of the human breast cancer resistance protein (BCRP/ABCG2) in an inward-facing conformation.The Heterodimeric ABC Transporter EfrCD Mediates Multidrug Efflux in Enterococcus faecalis.Molecular modelling and molecular dynamics of CFTR.Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structureCrystal structure of the human sterol transporter ABCG5/ABCG8.Mechanistic picture for conformational transition of a membrane transporter at atomic resolution.Predictive value of microparticle-associated tissue factor activity for permeability glycoprotein-mediated multidrug resistance in cancer.Analyses of conformational states of the transporter associated with antigen processing (TAP) protein in a native cellular membrane environment.Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function.Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).Advances in P-glycoprotein-based approaches for delivering anticancer drugs: pharmacokinetic perspective and clinical relevance.Intestinal transporters: enhanced absorption through P-glycoprotein-related drug interactions.A reciprocating twin-channel model for ABC transporters.P-glycoprotein and membrane roles in multidrug resistance.Modulators of the human ABCC2: hope from natural sources?
P2860
Q26738528-14A46E23-BFFB-4277-8042-7D5B41B1E82AQ27301793-1A2D1B79-486A-4566-8FD0-6F3B4541AFA6Q27345028-0997CB81-AB0F-4CEA-BF10-C9549EBABB69Q27680445-729F6720-E3DF-4730-B147-40EEE9844379Q28536673-7EBABB72-B9A6-4F95-B7E7-031FB24391AEQ30382600-BB330214-3A02-4BDD-B443-067F93C4BADBQ30631631-7FCE6FD7-3838-4108-B64E-F9600B95C7D1Q33458433-D1E2B887-15FA-4229-A5D8-13CA08634ABCQ33577108-D3B0130C-7DE5-4B3E-953A-6A75C1079962Q33750818-156D1082-845A-49AE-A3BE-885B96964E4CQ33757813-48BF59EE-1CD3-4679-B2B9-953454F2D874Q33802134-E09411CF-F01A-49B3-AF4D-F708C389BDC8Q33874106-7D38F420-C598-4D0C-BCA4-B8DF0C8A8DE4Q34107329-08E2A917-D17D-4366-B767-B3461A2C303FQ34979957-B16071CA-D82E-4DC6-BE61-95CAA20491F0Q35039337-9E002887-6ADF-4FFA-8E2E-BB275FCDD36FQ35121898-2529FE43-A29F-436A-A96F-C19B653733CDQ35152093-76A52840-CC49-4B40-8409-DDFFA2371B1FQ35167707-4AC70DC7-F73C-4BE2-BC1F-9DEE8403E0F8Q35234571-0D2F7245-0A9A-416B-86BC-99352703D708Q35306053-6C4F1129-8A90-4E67-97C6-032E0B31EEA6Q35363543-A9D331B3-1A79-4854-B883-EF1A5AAC9EA6Q35437120-AC79E21A-BB65-4A81-B838-40FEDEB29FC9Q35756130-624707CD-C412-4FA5-AC46-D7A29EB0321AQ35927508-7F2F3638-BB47-4AB2-AB84-4E0389B2F634Q36068568-2BFC496A-4B8D-430B-BBA4-D609ADAC2D56Q36158194-D0E1A591-25A9-46C6-898E-63F318BAB2B3Q36839792-A5B5299A-B3CB-4566-AB43-66FF942BAC15Q37135756-DC3166E5-EE2F-42CC-975F-749693907176Q37340797-58CD8893-384B-477B-891E-7D67569D8052Q37406897-9F4A243A-79EA-413A-8791-F45853EB3FA2Q37415627-32DD3598-9349-4C6F-A631-2E98D7FDA4BFQ37591245-128078CC-8CF9-43FE-84FC-595B453B2C87Q37612789-FE531656-C9B5-4317-9549-9CE76F7AF259Q37696966-413553D7-06AD-4A2C-BEB5-FE46A59B8B80Q38167822-037BF997-8E9F-40B2-BFC9-25A6C09305C3Q38202698-CBEE6543-2ECF-4A02-BDA7-E45DE71A4875Q38208521-9954543E-1013-46AF-B28D-8A04D9EC2937Q38523606-7CF10C8D-4E50-42D5-8F57-858D55FA59BAQ38614964-E9C04C44-EFBB-43EB-891C-05A07F9586C1
P2860
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structures of P-glycoprotein r ...... the nucleotide-binding domain
@ast
Structures of P-glycoprotein r ...... the nucleotide-binding domain
@en
Structures of P-glycoprotein r ...... the nucleotide-binding domain
@nl
type
label
Structures of P-glycoprotein r ...... the nucleotide-binding domain
@ast
Structures of P-glycoprotein r ...... the nucleotide-binding domain
@en
Structures of P-glycoprotein r ...... the nucleotide-binding domain
@nl
prefLabel
Structures of P-glycoprotein r ...... the nucleotide-binding domain
@ast
Structures of P-glycoprotein r ...... the nucleotide-binding domain
@en
Structures of P-glycoprotein r ...... the nucleotide-binding domain
@nl
P2093
P2860
P50
P3181
P356
P1476
Structures of P-glycoprotein r ...... the nucleotide-binding domain
@en
P2093
Alexandra Caya
Andrew B Ward
Cedric Govaerts
Chang-Wook Lee
Douglas J Swartz
Geoffrey Chang
Ina L Urbatsch
Lorena Martinez
Mark Villaluz
Paul Szewczyk
P2860
P304
P3181
P356
10.1073/PNAS.1309275110
P407
P577
2013-08-13T00:00:00Z