Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
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Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA.Structural and Functional Basis for Lipid Synergy on the Activity of the Antibacterial Peptide ABC Transporter McjD.Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoproteinGlobal marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structureIn silico analysis of the binding of anthelmintics to Caenorhabditis elegansP-glycoprotein 1.Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP.Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).Modulators of the human ABCC2: hope from natural sources?Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.Prenylflavonoid Isoxanthohumol Sensitizes MCF-7/ADR Cells to Doxorubicin Cytotoxicity via Acting as a Substrate of ABCB1.Schiff base derived from thiosemicarbazone and anthracene showed high potential in overcoming multidrug resistance in vitro with low drug resistance index.Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transportMultidrug resistance-associated protein 4 is a bile transporter of Clonorchis sinensis simulated by in silico docking.Combining Mass Spectrometry and X-Ray Crystallography for Analyzing Native-Like Membrane Protein Lipid Complexes.Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and transport efficiency.Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs.A significant mechanism of molecular recognition between bioflavonoids and P-glycoprotein leading to herb-drug interactions.Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer-associated P-glycoprotein during ATP hydrolysis.Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.The reliability of molecular dynamics simulations of the multidrug transporter P-glycoprotein in a membrane environment.Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.Coarse-grained molecular dynamics simulations reveal lipid access pathways in P-glycoprotein.Selective photodepletion of malignant T cells in extracorporeal photopheresis with selenorhodamine photosensitizers.Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.Reconstitution and functional studies of hamster P-glycoprotein in giant liposomes.Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)
P2860
Q27345028-DCC9A8D7-7B04-408E-9A5A-78FA17457791Q35756130-3B93C074-25CE-42A0-A652-2285B818B2A4Q36111073-237AEB47-2F8B-4F21-8DDB-2518EC39421CQ36578713-E86946C8-F882-4A29-A0EB-7BF75B17E070Q36839792-5622ABDA-5507-4FAD-B5DD-56E24D3A619BQ37541732-1CD9F869-F631-4864-BB27-F462B3122534Q37591245-707B70BF-AFFE-4622-A332-88908E960B5BQ37612488-E9CF4CEE-EE02-4D3C-90FB-51CA3E1E4EBFQ37696966-F44D8737-2ED3-4CBB-BCFE-BDC52696F355Q38614964-565930A8-BE48-426F-BC8D-83928ED6ED52Q40297334-EA14DF5D-5443-4B77-BFFD-FD97A950B3A0Q41175037-F94B6E12-068F-43DC-A9DF-07EFFE3EEDC0Q41282935-4F8295DA-21F0-4A39-8A62-3E1AC911411AQ41975402-604C5707-02D2-4406-8125-9533272621C6Q45418018-C381CB15-E14F-492A-9029-6BC29F2D1EF3Q45980813-5E001A44-900E-4652-806D-8F79C7E647F4Q46333054-C46770A6-BAC8-406F-A28A-3487D7C9F723Q47129909-FE9C1AF5-B38E-45F0-95D5-8BEEDC9AA403Q47329680-D24DA195-FD08-4F18-85E4-E5E3900A34FFQ47669250-A083BA97-3781-45CD-B5F5-4DB65D4DEE2CQ48100284-5FB4BE08-6FCC-4686-96B5-5AFAD5A0E9A3Q48165185-DD7FCD0E-B398-45A4-97AE-5F8F1C1D7FBCQ50026203-1910EFD6-708F-4FC8-98BB-AAA74CD7D405Q50043617-810D6A6F-03C2-48F0-996B-396CEC14CC89Q50195740-02387499-943C-4CE9-962A-730392A56866Q52602328-FDAAEA93-CA76-4061-9735-9567E4A3D48CQ55256284-71B44E95-EE91-4927-9E8D-3C774F4EE222Q59126511-5F10BE9B-F598-4216-8375-5AB1924D79EC
P2860
Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
description
2015 nî lūn-bûn
@nan
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Snapshots of ligand entry, mal ...... al movement in P-glycoprotein.
@ast
Snapshots of ligand entry, mal ...... al movement in P-glycoprotein.
@en
type
label
Snapshots of ligand entry, mal ...... al movement in P-glycoprotein.
@ast
Snapshots of ligand entry, mal ...... al movement in P-glycoprotein.
@en
prefLabel
Snapshots of ligand entry, mal ...... al movement in P-glycoprotein.
@ast
Snapshots of ligand entry, mal ...... al movement in P-glycoprotein.
@en
P2093
P2860
P1476
Snapshots of ligand entry, mal ...... al movement in P-glycoprotein.
@en
P2093
Aaron P McGrath
Geoffrey Chang
Houchao Tao
Ina L Urbatsch
Mark Villaluz
Paul Szewczyk
Qinghai Zhang
Rupak Doshi
Steven D Rees
Sung Chang Lee
P2860
P304
P356
10.1107/S1399004715000978
P577
2015-02-26T00:00:00Z