Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells.
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Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLSFrom Krebs to clinic: glutamine metabolism to cancer therapy.Racial disparity in metabolic regulation of cancer.Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachoneAlterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells.The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy.ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.Glutaminolysis as a target for cancer therapy.Drug-induced amino acid deprivation as strategy for cancer therapy.Glutamine at focus: versatile roles in cancer.Microvesicle Cargo and Function Changes upon Induction of Cellular Transformation.A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine.Glutaminase sustains cell survival via the regulation of glycolysis and glutaminolysis in colorectal cancerBalancing redox stress: anchorage-independent growth requires reductive carboxylation.Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition.Fluorination at the 4 position alters the substrate behavior of L-glutamine and L-glutamate: Implications for positron emission tomography of neoplasias.Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation.Glutaminases.Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.A small molecule regulator of tissue transglutaminase conformation inhibits the malignant phenotype of cancer cells
P2860
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P2860
Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells.
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2014 nî lūn-bûn
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2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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Mechanism by which a recently ...... tabolism in transformed cells.
@ast
Mechanism by which a recently ...... tabolism in transformed cells.
@en
Mechanism by which a recently ...... tabolism in transformed cells.
@nl
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label
Mechanism by which a recently ...... tabolism in transformed cells.
@ast
Mechanism by which a recently ...... tabolism in transformed cells.
@en
Mechanism by which a recently ...... tabolism in transformed cells.
@nl
prefLabel
Mechanism by which a recently ...... tabolism in transformed cells.
@ast
Mechanism by which a recently ...... tabolism in transformed cells.
@en
Mechanism by which a recently ...... tabolism in transformed cells.
@nl
P2093
P2860
P356
P1476
Mechanism by which a recently ...... tabolism in transformed cells.
@en
P2093
Clint A Stalnecker
Jon W Erickson
Mary Kate McBrayer
Ralph J DeBerardinis
Richard A Cerione
Scott M Ulrich
Sekar Ramachandran
Yunxing Li
P2860
P304
P356
10.1073/PNAS.1414056112
P407
P577
2014-12-29T00:00:00Z