Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain - Wikidata - awgldk - TriplyDB

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

http://www.wikidata.org/entity/Q27680754

about

The bromodomain: from epigenome reader to druggable target Protein lysine acetylation by p300/CBP Targeting bromodomains: epigenetic readers of lysine acetylation Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking.Fragment-based screening of the bromodomain of ATAD2.Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.Binding Mode of Acetylated Histones to Bromodomains: Variations on a Common Motif.Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.Progress in the Development of non-BET Bromodomain Chemical Probes.Selective targeting of epigenetic reader domains.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.A generic protocol for protein crystal dehydration using the HC1b humidity controller.9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens Cation-π interactions in CREBBP bromodomain inhibition: an electrostatic model for small-molecule binding affinity and selectivity.Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03115j.

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P2860

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

http://www.wikidata.org/entity/Q27680754

description

2013 nî lūn-bûn

@nan

2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Targeting Low-Druggability Bro ...... against the BAZ2B Bromodomain

@ast

Targeting Low-Druggability Bro ...... against the BAZ2B Bromodomain

@en

Targeting Low-Druggability Bro ...... against the BAZ2B Bromodomain

@nl

type

label

Targeting Low-Druggability Bro ...... against the BAZ2B Bromodomain

@ast

Targeting Low-Druggability Bro ...... against the BAZ2B Bromodomain

@en

Targeting Low-Druggability Bro ...... against the BAZ2B Bromodomain

@nl

prefLabel

Targeting Low-Druggability Bro ...... against the BAZ2B Bromodomain

@ast

Targeting Low-Druggability Bro ...... against the BAZ2B Bromodomain

@en

Targeting Low-Druggability Bro ...... against the BAZ2B Bromodomain

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P1433

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P1433

Journal of Medicinal Chemistry

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Targeting Low-Druggability Bro ...... against the BAZ2B Bromodomain

@en

P2093

Ildiko Felletar

http://www.w3.org/2001/XMLSchema#string

Joao R C Muniz

http://www.w3.org/2001/XMLSchema#string

Martin Philpott

http://www.w3.org/2001/XMLSchema#string

Tom Heightman

http://www.w3.org/2001/XMLSchema#string

P2860

Selective inhibition of BET bromodomains

Histone recognition and large-scale structural analysis of the human bromodomain family

Suppression of inflammation by a synthetic histone mimic

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water.

Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques.

A 'rule of three' for fragment-based lead discovery?

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.

Bromodomains as therapeutic targets.

Bromodomains as therapeutic targets in cancer.

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10183-7

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scholarly article

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2077934

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10.1021/JM401582C

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P433

24

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P478

56

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P50

Frank von Delft

Apirat Chaikuad

Fleur M Ferguson

P577

2013-12-27T00:00:00Z

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259199707

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24304323

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P932

3905694

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