Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold
about
Crystal structure of 5-chloro-N1-(5-phenyl-1H-pyrazol-3-yl)benzene-1,2-di-amine.In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninumMolecular Characterization and Functional Analysis of a Novel Calcium-Dependent Protein Kinase 4 from Eimeria tenellaSAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.Drugs in development for toxoplasmosis: advances, challenges, and current status.Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans.Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models.5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents.Drug target identification in protozoan parasites.Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice.5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum.Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.Crystal structure of 5-butyl-amino-3-methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carbaldehyde obtained from a microwave-assisted reaction using caesium carbonate as catalyst.Microbial protein targets: towards understanding and intervention.The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design.Evaluation of the basic functions of six calcium-dependent protein kinases in Toxoplasma gondii using CRISPR-Cas9 system.Toxoplasma calcium-dependent protein kinase 1 inhibitors: probing activity and resistance using cellular thermal shift assays.Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in the Acute Pig Model of Cryptosporidium hominis.Plasmodial Kinase Inhibitors: License to Cure?
P2860
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P2860
Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Potent and Selective Inhibitor ...... yrazole-4-carboxamide Scaffold
@ast
Potent and Selective Inhibitor ...... yrazole-4-carboxamide Scaffold
@en
Potent and Selective Inhibitor ...... yrazole-4-carboxamide Scaffold
@nl
type
label
Potent and Selective Inhibitor ...... yrazole-4-carboxamide Scaffold
@ast
Potent and Selective Inhibitor ...... yrazole-4-carboxamide Scaffold
@en
Potent and Selective Inhibitor ...... yrazole-4-carboxamide Scaffold
@nl
prefLabel
Potent and Selective Inhibitor ...... yrazole-4-carboxamide Scaffold
@ast
Potent and Selective Inhibitor ...... yrazole-4-carboxamide Scaffold
@en
Potent and Selective Inhibitor ...... yrazole-4-carboxamide Scaffold
@nl
P2093
P2860
P3181
P356
P1476
Potent and Selective Inhibitor ...... yrazole-4-carboxamide Scaffold
@en
P2093
Christophe L M J Verlinde
Erkang Fan
Ethan A Merritt
Jennifer A Geiger
Kasey Rivas
Katelyn R Keyloun
Kayode K Ojo
Kenneth M Comess
Kenneth P Robinson
Latha Kallur Siddaramaiah
P2860
P3181
P356
10.1021/ML400315S
P577
2014-01-09T00:00:00Z