about
Bivalent inhibitors of protein kinasesPotent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide ScaffoldConformation-Selective ATP-Competitive Inhibitors Control Regulatory Interactions and Noncatalytic Functions of Mitogen-Activated Protein KinasesConversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase ActivitySH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family.Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors.Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection.Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.Rapid profiling of protein kinase inhibitors by quantitative proteomics.The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites.Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastomaIn Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninumSAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.Bumped kinase inhibitor prohibits egression in Babesia bovisA hexylchloride-based catch-and-release system for chemical proteomic applications.A novel protein kinase is essential in bloodstream Trypanosoma bruceiA novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis.Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics.Druggable sensors of the unfolded protein response.5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents.Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis.Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites.Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics.Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src.Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α.Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.Rheostatic Control of Cas9-Mediated DNA Double Strand Break (DSB) Generation and Genome Editing.7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.Allosteric Modulation of JNK Docking Site Interactions with ATP-Competitive InhibitorsSubcellular drug targeting illuminates local kinase actionTargeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune DiabetesKinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling NetworksMulti-input chemical control of protein dimerization for programming graded cellular responsesDevelopment of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1
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P50
description
investigador
@es
researcher
@en
name
Dustin J Maly
@en
type
label
Dustin J Maly
@en
prefLabel
Dustin J Maly
@en
P31
P496
0000-0003-0094-0177