R -Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi - Wikidata - awgldk - TriplyDB

R -Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi

R -Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi

http://www.wikidata.org/entity/Q27684247

about

Expanding the Binding Envelope of CYP51 Inhibitors TargetingTrypanosoma cruziwith 4-Aminopyridyl-Based Sulfonamide Derivatives 4-Aminopyridyl-Based CYP51 Inhibitors as Anti- Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery Drug strategies targeting CYP51 in neglected tropical diseases Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.

P2860

Q27683570-06D21709-63F8-4246-BC81-0C077109FEAC Q27684956-840624E7-4DA1-4A39-AD10-07AF230AD3FC Q28066944-26B0817A-5E55-48FC-B1CF-33FA54A20BDD Q28544037-0FDAC276-26BE-404A-AE6E-7B6F7402AE37 Q28545842-77C7366B-3BFF-44C6-BA46-1F0ABE88AADD Q34622554-253FCDA2-AEDD-49A1-944D-690B9606B67B Q34701325-D4EC68FF-C5B1-4FB3-B521-42156D44289A Q36808252-81E0AF9E-D02F-44D2-A0A4-93F7964B7355 Q48342608-2E065E15-90A7-43DE-B9B2-694E12796BE8

P2860

R -Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi

http://www.wikidata.org/entity/Q27684247

description

2014 nî lūn-bûn

@nan

2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年学术文章

@wuu

2014年学术文章

@zh-cn

2014年学术文章

@zh-hans

2014年学术文章

@zh-my

2014年学术文章

@zh-sg

2014年學術文章

@yue

name

R -Configuration of 4-Aminopyr ...... cacy Against Trypanosoma cruzi

@ast

R -Configuration of 4-Aminopyr ...... cacy Against Trypanosoma cruzi

@en

R -Configuration of 4-Aminopyr ...... cacy Against Trypanosoma cruzi

@nl

type

label

R -Configuration of 4-Aminopyr ...... cacy Against Trypanosoma cruzi

@ast

R -Configuration of 4-Aminopyr ...... cacy Against Trypanosoma cruzi

@en

R -Configuration of 4-Aminopyr ...... cacy Against Trypanosoma cruzi

@nl

prefLabel

R -Configuration of 4-Aminopyr ...... cacy Against Trypanosoma cruzi

@ast

R -Configuration of 4-Aminopyr ...... cacy Against Trypanosoma cruzi

@en

R -Configuration of 4-Aminopyr ...... cacy Against Trypanosoma cruzi

@nl

P1433

Q27684247-7AA383D9-F2B2-41CA-816E-A6BC80F95160

P1476

Q27684247-94865304-9499-4EAF-AAC9-7EA36D1D4E16

P2093

Q27684247-389CE908-7FB9-4D28-843F-131BFD571C48

Q27684247-42B3F4D3-BCEA-42FB-AEB1-FB4CB0FBF3AB

Q27684247-603FF062-FA72-486B-9D5E-9BD8B5D87B8C

Q27684247-842816BD-188B-4A74-A2C2-53AA123C5FA8

Q27684247-ACEA4776-7437-429E-8E81-062D5401EE82

Q27684247-F2F68D3C-3119-495C-A1C7-40EA4D1F8042

Q27684247-F7F6F7A0-22D0-4B81-BBD9-5A3842589064

P2860

Q27684247-023860D2-1950-4311-8A1A-C666B8FC10A2

Q27684247-1FBBB434-5069-4521-8B0F-BA615C89E47A

Q27684247-3055655D-5A83-4C10-87DB-4C8D966001D4

Q27684247-5A45B78F-62A7-49F0-9108-AC1CA8C3A3BF

Q27684247-5C6C98A1-AABB-48A0-9F3A-E555333EAB12

Q27684247-67E9E74A-E91A-48A1-ACC1-B6E1CABB635B

Q27684247-759E5201-0B7C-4272-A471-E98E303A78ED

Q27684247-7CD88158-2467-44B1-946D-95E52FF79295

Q27684247-BEAF15A2-E138-4008-8ED2-D5228483CC70

Q27684247-CF6E072D-1375-4688-8C35-558980749C25

P304

Q27684247-46027F7A-BDB8-4C28-8855-3E4ABBC60B38

P31

Q27684247-5367BDDE-8546-45D4-BFB0-51EB06B73689

P3181

Q27684247-C323BD8F-ED1E-48EA-B162-0A62F88A202D

P356

Q27684247-3A3A5ED3-8267-42FF-8616-6B014AE1255D

P433

Q27684247-CD781A6E-C7C1-402F-AD99-2AD179C0E05A

P478

Q27684247-512D5C66-A336-42D5-8C79-32EDE9198B3E

P50

Q27684247-59EEB04C-25CD-460C-9F11-E1F480450AC8

P577

Q27684247-7C4C5091-0675-4C77-89E5-5A7651564E08

P5875

Q27684247-597BD77E-7F43-440C-A0A9-67B055BEF630

P698

Q27684247-F54DE2C7-1976-4850-86A3-EF829951CDE8

P921

Q27684247-7DF386C4-D8BE-4B25-A4AE-3C58310084EA

Q27684247-C74F9237-A04E-4B47-A5DC-7B035C6CF874

Q27684247-F050160D-CAF8-4EA6-B673-3DD710481CA9

P932

Q27684247-DEB208F9-81BC-4452-9FD0-7C2E02374334

P3181

P356

P1433

ACS Medicinal Chemistry Letters

P1476

R -Configuration of 4-Aminopyr ...... cacy Against Trypanosoma cruzi

@en

P2093

Claudia M Calvet

http://www.w3.org/2001/XMLSchema#string

Debora F Vieira

http://www.w3.org/2001/XMLSchema#string

Jun Yong Choi

http://www.w3.org/2001/XMLSchema#string

Larissa M Podust

http://www.w3.org/2001/XMLSchema#string

Michael D Cameron

http://www.w3.org/2001/XMLSchema#string

Shamila S Gunatilleke

http://www.w3.org/2001/XMLSchema#string

William R Roush

http://www.w3.org/2001/XMLSchema#string

P2860

Induction of resistance to azole drugs in Trypanosoma cruzi.

VNI cures acute and chronic experimental Chagas disease

Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

Rational Development of 4-Aminopyridyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 as Anti-Chagas Agents

Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens.

Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.

Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts

Application of the three-dimensional structures of protein target molecules in structure-based drug design.

P304

434-9

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

5106243

http://www.w3.org/2001/XMLSchema#string

P356

10.1021/ML500010M

http://www.w3.org/2001/XMLSchema#string

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

5

http://www.w3.org/2001/XMLSchema#string

P50

James H McKerrow

P577

2014-04-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

262885911

http://www.w3.org/2001/XMLSchema#string

P698

24900854

http://www.w3.org/2001/XMLSchema#string

P921

Aagianik kimischri

Trypanosoma cruzi

P932

4027616

http://www.w3.org/2001/XMLSchema#string