A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.
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The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cellsGenetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association StudiesInferring gene-phenotype associations via global protein complex network propagationInsulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention.Pharmacogenetics of Anti-Diabetes Drugs.Population specific impact of genetic variants in KCNJ11 gene to type 2 diabetes: a case-control and meta-analysis study.ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations.The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetesClinical and metabolic features of adult-onset diabetes caused by ABCC8 mutations.Genetic variants in potassium channels are associated with type 2 diabetes in a Mongolian population.Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and NoiseDifferential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channelPharmacogenomics in type II diabetes mellitus management: Steps toward personalized medicine.Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells.Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients.Regulation of ATP production by mitochondrial Ca(2+).Dorothy Hodgkin Lecture 2014. Understanding genes identified by genome-wide association studies for type 2 diabetes.Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.Neonatal Diabetes and the KATP Channel: From Mutation to Therapy.Genetic factors in pathogenesis of diabetes mellitus after kidney transplantation.Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals.KCNJ11 tetramer:ABCC8 tetramer binds 4xATP; closing the channelFamilial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations.Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future Perspectives.Heterozygous ABCC8 mutations are a cause of MODY
P2860
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P2860
A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A rare mutation in ABCC8/SUR1 ...... ith type 2 diabetes in adults.
@ast
A rare mutation in ABCC8/SUR1 ...... ith type 2 diabetes in adults.
@en
A rare mutation in ABCC8/SUR1 ...... ith type 2 diabetes in adults.
@nl
type
label
A rare mutation in ABCC8/SUR1 ...... ith type 2 diabetes in adults.
@ast
A rare mutation in ABCC8/SUR1 ...... ith type 2 diabetes in adults.
@en
A rare mutation in ABCC8/SUR1 ...... ith type 2 diabetes in adults.
@nl
altLabel
A rare mutation in ABCC8/SUR1 ...... with type 2 diabetes in adults
@en
prefLabel
A rare mutation in ABCC8/SUR1 ...... ith type 2 diabetes in adults.
@ast
A rare mutation in ABCC8/SUR1 ...... ith type 2 diabetes in adults.
@en
A rare mutation in ABCC8/SUR1 ...... ith type 2 diabetes in adults.
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
A rare mutation in ABCC8/SUR1 ...... ith type 2 diabetes in adults.
@en
P2093
Guillaume Charpentier
Guy A Rutter
Jean-François Gautier
Jean-Pierre Riveline
Jocelyn M Baldwin
Tamara J Nicolson
Tarvinder K Taneja
P2860
P304
P3181
P356
10.2337/DB07-1547
P407
P577
2008-06-01T00:00:00Z