ATP4- mediates closure of pancreatic beta-cell ATP-sensitive potassium channels by interaction with 1 of 4 identical sites
about
Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological featuresHow ATP inhibits the open K(ATP) channelHyperinsulinemic Hypoglycemia - The Molecular MechanismsPancreatic regulation of glucose homeostasisThe Nucleotide-Binding Sites of SUR1: A Mechanistic ModelA rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.The carboxyl termini of K(ATP) channels bind nucleotidesKir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactionsATP-sensitive potassium channelopathies: focus on insulin secretionA gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome.Concerted gating mechanism underlying KATP channel inhibition by ATP.The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetesATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transferGating mechanism of KATP channels: function fits form.From molecule to malady.Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels.The unusual stoichiometry of ADP activation of the KATP channel.Current understanding of K ATP channels in neonatal diseases: focus on insulin secretion disorders.Modulation of Ionic Channels and Insulin Secretion by Drugs and Hormones in Pancreatic Beta Cells.Identification of residues contributing to the ATP binding site of Kir6.2.Incomplete dissociation of glibenclamide from wild-type and mutant pancreatic K ATP channels limits their recovery from inhibition.Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.ATP and sulfonylurea linkage in the K(ATP) channel solves a diabetes puzzlerFunctional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.
P2860
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P2860
ATP4- mediates closure of pancreatic beta-cell ATP-sensitive potassium channels by interaction with 1 of 4 identical sites
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
@wuu
name
ATP4- mediates closure of panc ...... on with 1 of 4 identical sites
@ast
ATP4- mediates closure of panc ...... on with 1 of 4 identical sites
@en
ATP4- mediates closure of panc ...... on with 1 of 4 identical sites
@nl
type
label
ATP4- mediates closure of panc ...... on with 1 of 4 identical sites
@ast
ATP4- mediates closure of panc ...... on with 1 of 4 identical sites
@en
ATP4- mediates closure of panc ...... on with 1 of 4 identical sites
@nl
prefLabel
ATP4- mediates closure of panc ...... on with 1 of 4 identical sites
@ast
ATP4- mediates closure of panc ...... on with 1 of 4 identical sites
@en
ATP4- mediates closure of panc ...... on with 1 of 4 identical sites
@nl
P2093
P3181
P1433
P1476
ATP4- mediates closure of panc ...... on with 1 of 4 identical sites
@en
P2093
C Schwanstecher
E Markworth
M Schwanstecher
P304
P3181
P356
10.2337/DIABETES.49.9.1413
P407
P577
2000-09-01T00:00:00Z