Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.
about
Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptorIdentification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.At short telomeres Tel1 directs early replication and phosphorylates Rif1.DNA damage response-mediated degradation of Ho endonuclease via the ubiquitin system involves its nuclear export.Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmanninMEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae.Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae.Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA.Def1p is involved in telomere maintenance in budding yeast.The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand BreaksReplication protein A is sequentially phosphorylated during meiosis.DNA stimulates Mec1-mediated phosphorylation of replication protein A.A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae.A proteome-wide analysis of kinase-substrate network in the DNA damage response.A two-step model for senescence triggered by a single critically short telomere.Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutantsInositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinasesTelomere maintenance by intracellular signals: new kid on the block?To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae.A telomeric repeat sequence adjacent to a DNA double-stranded break produces an anticheckpoint.Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenanceA dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1.Meiotic recombination hot spots and cold spots.Telomerase recruitment in Saccharomyces cerevisiae is not dependent on Tel1-mediated phosphorylation of Cdc13.ATM, a central controller of cellular responses to DNA damage.Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinaseATM function and telomere stability.Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe.Kinase-independent functions of TEL1 in telomere maintenance.A quantitative assay for telomere protection in Saccharomyces cerevisiaeReduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair.Budding yeast ATM/ATR control meiotic double-strand break (DSB) levels by down-regulating Rec114, an essential component of the DSB-machinery.Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a.Yeast pol4 promotes tel1-regulated chromosomal translocations.The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation.Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity
P2860
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P2860
Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Protein kinase activity of Tel ...... the human ATM protein kinase.
@ast
Protein kinase activity of Tel ...... the human ATM protein kinase.
@en
Protein kinase activity of Tel ...... the human ATM protein kinase.
@nl
type
label
Protein kinase activity of Tel ...... the human ATM protein kinase.
@ast
Protein kinase activity of Tel ...... the human ATM protein kinase.
@en
Protein kinase activity of Tel ...... the human ATM protein kinase.
@nl
altLabel
Protein kinase activity of Tel ...... o the human ATM protein kinase
@en
prefLabel
Protein kinase activity of Tel ...... the human ATM protein kinase.
@ast
Protein kinase activity of Tel ...... the human ATM protein kinase.
@en
Protein kinase activity of Tel ...... the human ATM protein kinase.
@nl
P2860
P356
P1476
Protein kinase activity of Tel ...... the human ATM protein kinase.
@en
P2093
J C Mallory
P2860
P304
P356
10.1073/PNAS.250475697
P407
P577
2000-12-05T00:00:00Z