Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein
about
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damageInteraction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeastInteractions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathwaysRegulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decayIdentification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.IGHMBP2 is a ribosome-associated helicase inactive in the neuromuscular disorder distal SMA type 1 (DSMA1)The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAsCloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 proteinFunctional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulationUnusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activitySMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeastSplicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex componentsItt1p, a novel protein inhibiting translation termination in Saccharomyces cerevisiaeNonsense-mediated mRNA decay: novel mechanistic insights and biological impactHepatitis C virus internal ribosome entry site-dependent translation in Saccharomyces cerevisiae is independent of polypyrimidine tract-binding protein, poly(rC)-binding protein 2, and La proteinA point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 proteinStructural and functional insights into the human Upf1 helicase coreDed1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase.Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover.Fine-tuning of translation termination efficiency in Saccharomyces cerevisiae involves two factors in close proximity to the exit tunnel of the ribosome.Tpa1p is part of an mRNP complex that influences translation termination, mRNA deadenylation, and mRNA turnover in Saccharomyces cerevisiae.Posttranscriptional control of gene expression in yeast.Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3pDbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export.Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeastOverexpression of Upf1p compensates for mitochondrial splicing deficiency independently of its role in mRNA surveillance.Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough.Targeting of aberrant mRNAs to cytoplasmic processing bodies.Mtt1 is a Upf1-like helicase that interacts with the translation termination factors and whose overexpression can modulate termination efficiency.The yeast SEN1 gene is required for the processing of diverse RNA classesNonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryRoles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complexEvidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathwayAttenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression
P2860
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P2860
Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein
description
1996 nî lūn-bûn
@nan
1996 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Genetic and biochemical charac ...... se regions of the Upf1 protein
@ast
Genetic and biochemical charac ...... se regions of the Upf1 protein
@en
Genetic and biochemical charac ...... e regions of the Upf1 protein.
@nl
type
label
Genetic and biochemical charac ...... se regions of the Upf1 protein
@ast
Genetic and biochemical charac ...... se regions of the Upf1 protein
@en
Genetic and biochemical charac ...... e regions of the Upf1 protein.
@nl
prefLabel
Genetic and biochemical charac ...... se regions of the Upf1 protein
@ast
Genetic and biochemical charac ...... se regions of the Upf1 protein
@en
Genetic and biochemical charac ...... e regions of the Upf1 protein.
@nl
P2093
P2860
P3181
P356
P1476
Genetic and biochemical charac ...... se regions of the Upf1 protein
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.16.10.5477
P407
P577
1996-10-01T00:00:00Z