Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.
about
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeastRegulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAsCloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 proteinComparative genomics and evolution of proteins involved in RNA metabolismComplexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cellsp68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5' splice site duplex.The hDcp2 protein is a mammalian mRNA decapping enzymeHuman Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structuresIdentification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexesSMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeastUsing the cre-lox recombination system to assess functional impairment caused by amino acid substitutions in yeast proteinsProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsDExD/H-box RNA helicases in ribosome biogenesisNonsense-mediated mRNA decay: inter-individual variability and human diseaseTemperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover.Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.Yeast Edc3 targets RPS28B mRNA for decapping by binding to a 3' untranslated region decay-inducing regulatory element.Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay.NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae.Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover.Physiological basis of copper tolerance of Saccharomyces cerevisiae nonsense-mediated mRNA decay mutants.The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5pRole for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay.A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast.Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3pNuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p.Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeastA novel nuclear import pathway for the transcription factor TFIIS.Ebs1p, a negative regulator of gene expression controlled by the Upf proteins in the yeast Saccharomyces cerevisiae.Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough.Genome-wide protein interaction screens reveal functional networks involving Sm-like proteinsGenetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 proteinNonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryRecruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1The protein family of RNA helicases
P2860
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P2860
Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.
description
1995 nî lūn-bûn
@nan
1995 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Identification of a novel comp ...... an interacting protein screen.
@ast
Identification of a novel comp ...... an interacting protein screen.
@en
Identification of a novel comp ...... an interacting protein screen.
@nl
type
label
Identification of a novel comp ...... an interacting protein screen.
@ast
Identification of a novel comp ...... an interacting protein screen.
@en
Identification of a novel comp ...... an interacting protein screen.
@nl
prefLabel
Identification of a novel comp ...... an interacting protein screen.
@ast
Identification of a novel comp ...... an interacting protein screen.
@en
Identification of a novel comp ...... an interacting protein screen.
@nl
P3181
P356
P1433
P1476
Identification of a novel comp ...... an interacting protein screen.
@en
P304
P3181
P356
10.1101/GAD.9.4.437
P407
P577
1995-02-15T00:00:00Z