DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts
about
Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signalingFunctional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilonATR: an essential regulator of genome integrityXenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA endsCut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin.A novel protein activity mediates DNA binding of an ATR-ATRIP complex.The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.Physical interaction between replication protein A (RPA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1.ATR activation and replication fork restart are defective in FANCM-deficient cells.Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts.Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaksPhosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminusDNA is a co-factor for its own replication in Xenopus egg extracts.The structural determinants of checkpoint activationSite-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structuresDNA damage checkpoint control in cells exposed to ionizing radiation.XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus.Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryosAbsence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phasesDNA damage-induced replication arrest in Xenopus egg extractsStudy of the DNA damage checkpoint using Xenopus egg extracts.Analyzing the ATR-mediated checkpoint using Xenopus egg extractsXRCC1 interacts with the p58 subunit of DNA Pol alpha-primase and may coordinate DNA repair and replication during S phase.Control of DNA replication by the nucleus/cytoplasm ratio in Xenopus.TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.The S-phase checkpoint: targeting the replication fork.The Intra-S Checkpoint Responses to DNA Damage.Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.The DNA damage checkpoint response to replication stress: A Game of Forks.Molecular mechanisms involved in initiation of the DNA damage response.A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.ATM/ATR-independent inhibition of cyclin B accumulation in response to hydroxyurea in nontransformed cell lines is altered in tumour cell lines.Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling.Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts.Differential activation of intra-S-phase checkpoint in response to tripchlorolide and its effects on DNA replication.Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities.Myosin 16 levels fluctuate during the cell cycle and are downregulated in response to DNA replication stress.APE2 promotes DNA damage response pathway from a single-strand break.
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P2860
DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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name
DNA replication is required fo ...... ed DNA in Xenopus egg extracts
@ast
DNA replication is required fo ...... ed DNA in Xenopus egg extracts
@en
type
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DNA replication is required fo ...... ed DNA in Xenopus egg extracts
@ast
DNA replication is required fo ...... ed DNA in Xenopus egg extracts
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prefLabel
DNA replication is required fo ...... ed DNA in Xenopus egg extracts
@ast
DNA replication is required fo ...... ed DNA in Xenopus egg extracts
@en
P2093
P2860
P356
P1476
DNA replication is required fo ...... ed DNA in Xenopus egg extracts
@en
P2093
Matthew P Stokes
Ruth Van Hatten
W Matthew Michael
P2860
P304
P356
10.1083/JCB.200204127
P407
P577
2002-09-03T00:00:00Z