Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1
about
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeLKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Cell polarity signaling in the plasticity of cancer cell invasivenessCrystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptorPAR-1 kinase regulates epithelial detachment and directional protrusion of migrating border cells.Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.LKB1, the multitasking tumour suppressor kinaseFunctional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.STRAD in Peutz-Jeghers syndrome and sporadic cancers.PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells.Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancersAberrant beta-catenin signaling in tuberous sclerosis.Contraction signaling to glucose transport in skeletal muscle.AMP-activated protein kinase and the regulation of glucose transport.Extending from PARs in Caenorhabditis elegans to homologues in Haemonchus contortus and other parasitic nematodes.LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.LKB1; linking cell structure and tumor suppression.LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling.Role of LKB1-SAD/MARK pathway in neuronal polarization.The tumor suppressor kinase LKB1: lessons from mouse models.Celiac Disease: Role of the Epithelial Barrier.Analysis of detergent-resistant membranes of Helicobacter pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity.A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinomaAtypical PKC phosphorylates microtubule affinity-regulating kinase 4 in vitro.Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis.Complete germline deletion of the STK11 gene in a family with Peutz-Jeghers syndrome.Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis.Micellar nanocomplexes for biomagnetic delivery of intracellular proteins to dictate axon formation during neuronal development.Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice.Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report.LKB1 gene alterations in surgically resectable adenocarcinoma of the lung.The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome
P2860
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P2860
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Regulation of the Wnt signalli ...... z-Jeghers syndrome kinase LKB1
@ast
Regulation of the Wnt signalli ...... z-Jeghers syndrome kinase LKB1
@en
Regulation of the Wnt signalli ...... z-Jeghers syndrome kinase LKB1
@nl
type
label
Regulation of the Wnt signalli ...... z-Jeghers syndrome kinase LKB1
@ast
Regulation of the Wnt signalli ...... z-Jeghers syndrome kinase LKB1
@en
Regulation of the Wnt signalli ...... z-Jeghers syndrome kinase LKB1
@nl
prefLabel
Regulation of the Wnt signalli ...... z-Jeghers syndrome kinase LKB1
@ast
Regulation of the Wnt signalli ...... z-Jeghers syndrome kinase LKB1
@en
Regulation of the Wnt signalli ...... z-Jeghers syndrome kinase LKB1
@nl
P2093
P2860
P356
P1433
P1476
Regulation of the Wnt signalli ...... z-Jeghers syndrome kinase LKB1
@en
P2093
Darrin Smith
James Spicer
Neville Young
Richard Elliott
Sydonia Rayter
P2860
P2888
P304
P356
10.1038/SJ.ONC.1206669
P407
P577
2003-07-24T00:00:00Z
P5875
P6179
1012735242