Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.
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The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathwaysA pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation.LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndromeA novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Indian patients.Population-based estimate of sibling risk for preterm birth, preterm premature rupture of membranes, placental abruption and pre-eclampsia.Scribble at the crossroads.Spectrum of LKB1, EGFR, and KRAS mutations in chinese lung adenocarcinomas.Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function.Hereditary hamartomatous polyposis syndromes: understanding the disease risks as children reach adulthood.A novel mutation in STK11 gene is associated with Peutz-Jeghers syndrome in Chinese patients.Disease variants in genomes of 44 centenarians.Endopancreatic bile duct cholangiocarcinoma in a patient with peutz-jeghers syndrome.Brush border myosin Ia has tumor suppressor activity in the intestine.AMP-activated protein kinase regulates the assembly of epithelial tight junctions.Clinical characteristics and STK11 gene mutations in Chinese children with Peutz-Jeghers syndromeCytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapyMolecular Heterogeneity of Ewing Sarcoma as Detected by Ion Torrent SequencingSuppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization.Three novel mutations of STK11 gene in Chinese patients with Peutz-Jeghers syndrome.Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma.AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancer.Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activationA Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma.LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistenceLKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activationIdentification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis.Epithelial junctions and polarity: complexes and kinases.Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.LKB1; linking cell structure and tumor suppression.Racial and Ethnic Differences in the Epidemiology and Genomics of Lung Cancer.Correlation between genotype and phenotype in three families with Peutz-Jeghers Syndrome.Molecular mechanisms of tumor suppression by LKB1.LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor.The LKB1 complex-AMPK pathway: the tree that hides the forestExceptional durable response to everolimus in a patient with biphenotypic breast cancer harboring an STK11 variant.A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties.Chromosome 19p13.3 deletion in a child with Peutz-Jeghers syndrome, congenital heart defect, high myopia, learning difficulties and dysmorphic features: Clinical and molecular characterization of a new contiguous gene syndrome.AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells.Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germline mutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancer risk: case report of a Chinese patient.
P2860
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P2860
Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Functional analysis of Peutz-J ...... pathway and the cell polarity.
@ast
Functional analysis of Peutz-J ...... pathway and the cell polarity.
@en
Functional analysis of Peutz-J ...... pathway and the cell polarity.
@nl
type
label
Functional analysis of Peutz-J ...... pathway and the cell polarity.
@ast
Functional analysis of Peutz-J ...... pathway and the cell polarity.
@en
Functional analysis of Peutz-J ...... pathway and the cell polarity.
@nl
prefLabel
Functional analysis of Peutz-J ...... pathway and the cell polarity.
@ast
Functional analysis of Peutz-J ...... pathway and the cell polarity.
@en
Functional analysis of Peutz-J ...... pathway and the cell polarity.
@nl
P2093
P2860
P356
P1476
Functional analysis of Peutz-J ...... pathway and the cell polarity.
@en
P2093
Annette Baas
Christelle Forcet
Hans Clevers
Hélène Gaude
Laurence Fournier
Marc Billaud
Marko Salmi
Sandrine Etienne-Manneville
Sylviane Olschwang
Sébastien Debilly
P2860
P304
P356
10.1093/HMG/DDI139
P577
2005-03-30T00:00:00Z