DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
about
Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitinWerner syndrome protein interacts functionally with translesion DNA polymerasesMolecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patientsSomatic hypermutation of the AID transgene in B and non-B cellsMutations in human DNA polymerase eta motif II alter bypass of DNA lesionsThe translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutationRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationActivation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationHepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η.AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversificationStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesA tribute to Michael S. NeubergerDeletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctionsAltered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant miceBiochemical analysis of DNA polymerase η fidelity in the presence of replication protein AMicrosatellite interruptions stabilize primate genomes and exist as population-specific single nucleotide polymorphisms within individual human genomesMsh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombinationPolymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutationExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversificationADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cellsATAD5 deficiency decreases B cell division and Igh recombinationAn overview of Y-Family DNA polymerases and a case study of human DNA polymerase ηTemporal regulation of Ig gene diversification revealed by single-cell imaging.The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.A role for PCNA ubiquitination in immunoglobulin hypermutation.Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversificationMutation of the little finger domain in human DNA polymerase η alters fidelity when copying undamaged DNAMutational fingerprints of aging.Refining the Neuberger model: Uracil processing by activated B cells.Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.Somatic immunoglobulin hypermutation.AID and somatic hypermutation.Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.
P2860
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P2860
DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
description
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
scientific article (publication date: June 2001)
@en
vedecký článok (publikovaný 2001-06)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd in 2001-06)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в червні 2001
@uk
مقالة علمية (نشرت في يونيو 2001)
@ar
name
DNA polymerase eta is an A-T m ...... immunoglobulin variable genes
@ast
DNA polymerase eta is an A-T m ...... immunoglobulin variable genes
@en
DNA polymerase eta is an A-T m ...... immunoglobulin variable genes
@nl
type
label
DNA polymerase eta is an A-T m ...... immunoglobulin variable genes
@ast
DNA polymerase eta is an A-T m ...... immunoglobulin variable genes
@en
DNA polymerase eta is an A-T m ...... immunoglobulin variable genes
@nl
prefLabel
DNA polymerase eta is an A-T m ...... immunoglobulin variable genes
@ast
DNA polymerase eta is an A-T m ...... immunoglobulin variable genes
@en
DNA polymerase eta is an A-T m ...... immunoglobulin variable genes
@nl
P2093
P3181
P356
P1433
P1476
DNA polymerase eta is an A-T m ...... immunoglobulin variable genes
@en
P2093
P2888
P304
P3181
P356
10.1038/88740
P407
P577
2001-06-01T00:00:00Z
P6179
1040230141