The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation - Wikidata - awgldk - TriplyDB

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

http://www.wikidata.org/entity/Q24537096

about

Promiscuous DNA synthesis by human DNA polymerase θ A unique error signature for human DNA polymerase nu Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions A role for DRAK2 in the germinal center reaction and the antibody response Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies Microhomology-mediated end joining: new players join the team The transcription factor TFII-I promotes DNA translesion synthesis and genomic stability Mechanism of suppression of chromosomal instability by DNA polymerase POLQ Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.Overexpression of POLQ confers a poor prognosis in early breast cancer patients.AID and somatic hypermutation.Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation DNA polymerases and somatic hypermutation of immunoglobulin genes Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.Involvement of Rad18 in somatic hypermutation DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.Mechanism and regulation of class switch recombination AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota Requirement for autophagy in the long-term persistence but not initial formation of memory B cells.Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity.A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines Genome-Wide Analysis Reveals Selective Modulation of microRNAs and mRNAs by Histone Deacetylase Inhibitor in B Cells Induced to Undergo Class-Switch DNA Recombination and Plasma Cell Differentiation.Evaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repair Linking DNA polymerase theta structure and function in health and disease DNA repair in antibody somatic hypermutation.DNA polymerase POLQ and cellular defense against DNA damage.Low-fidelity DNA synthesis by human DNA polymerase theta.DNA replication to aid somatic hypermutation Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.Response to "Mutation frequency vs. mutation patterns: a comparison of the results in spleen and Peyer's patches"

P2860

8aef6bec86059ad325735ee4b95e9a568d5270c0

P248

Q24298854-BA8A7951-E875-46C9-895A-0C2EB4B4C52C Q24318524-0A0BE11C-A246-49C6-B9A7-58FF1F85735B Q24324903-5385DA91-B6EC-445D-9FA6-1DD527A416F4 Q24623341-63EC514F-BCB0-41BC-AB3F-04FD08403A16 Q24630648-338E79A8-0B2E-40AD-B68D-AC474202A8B3 Q24633098-57B00158-B64E-4ADE-A424-CC0861BC9EF0 Q24645030-CB7948E6-D53E-4A5E-8A0D-6834CAA195C0 Q28235340-31F9FAED-8446-4190-9CBB-760CAA591387 Q28468576-600718AC-0FAA-49AC-8EF2-CBD7284666B6 Q28539614-8E09AFE7-C9E8-46F6-AEA4-0B44668D3797 Q28543483-C70B0DB3-CBA3-45A9-BF08-112A80D1E556 Q33299999-EDC35A88-6CD3-44FC-928C-589E8E241E14 Q33628866-298696D0-B6C7-4F4C-A615-391D7C81D922 Q34051213-AF08AB75-CA97-489C-8FE1-A1AE782E64B2 Q34118000-A8E8F17B-D0EB-4359-99E6-5FBC05961EB1 Q34333819-97559B28-3460-4455-BB33-B00D8EAD72B5 Q34360690-37411CA1-0EA4-45B3-BF30-57BEAAF26C35 Q34514909-4036F23D-C6AD-45C6-B2CB-634B7EEE4F24 Q34551859-048B0A6A-F183-4877-886D-3018720BF2CF Q34595025-1BE07683-F96B-47F7-B7EC-1F9EF30DD19A Q34764888-2711B94C-5A7A-4A4D-B746-7C9CBF657C70 Q35068183-93B4E219-3D32-4C3E-99A3-EFDBBE6F03CC Q35119826-E8DDF9AF-1051-471F-B2D0-5FDA6CAB3103 Q35131714-CAEBFA0B-DAF3-416A-BBDA-BDCD0D9B5CE8 Q35163564-2233459A-DDEB-4D15-9C29-2C16F5346DBA Q35758815-777C7497-4C16-4062-A174-DB5A796CF615 Q35792481-A14F99A4-04F2-454F-89CF-050D7FCA0A13 Q35792957-7A1B9088-8CA0-41DA-8B96-073A7955FA0B Q35980902-EE4D7598-E8F3-4616-A4DB-A6F2DE9D604C Q36211150-F22454D6-EA07-45F1-A794-4F0DB9E53FB7 Q36238936-35176C0A-9E48-4E1C-9FD9-D2FF61ED17D7 Q36367583-CB82FBEB-F8D3-45C8-B577-59695ADA281E Q36389685-DE6D4176-7C44-4601-826C-46CAA545343B Q36469682-C31BE7F3-CEBA-4809-9ED8-EB8525838F76 Q36493831-4BEE3B17-945C-4F3B-B88E-20CF10C9562A Q36501461-38D71CD0-98BD-43CC-8736-9E730FD9DA4B Q36740110-8CB1C992-5B3F-44F3-A8C3-4324CC5DB859 Q36751819-D47898B0-8A6C-4612-8723-78F0949FC2BD Q36923850-CC3FF47E-BA9F-4314-A229-0FC62E88C13F Q36961460-BF36632A-DE8E-444B-848C-1104AC1CE92F

P2860

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

http://www.wikidata.org/entity/Q24537096

description

2005 nî lūn-bûn

@nan

2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

The translesion DNA polymerase ...... lin gene somatic hypermutation

@ast

The translesion DNA polymerase ...... lin gene somatic hypermutation

@en

The translesion DNA polymerase ...... lin gene somatic hypermutation

@nl

type

label

The translesion DNA polymerase ...... lin gene somatic hypermutation

@ast

The translesion DNA polymerase ...... lin gene somatic hypermutation

@en

The translesion DNA polymerase ...... lin gene somatic hypermutation

@nl

prefLabel

The translesion DNA polymerase ...... lin gene somatic hypermutation

@ast

The translesion DNA polymerase ...... lin gene somatic hypermutation

@en

The translesion DNA polymerase ...... lin gene somatic hypermutation

@nl

P1433

Q24537096-682DD892-7977-451B-A0C5-2704C56A6890

P1476

Q24537096-B2A1C2EA-5311-4795-8F67-B636F255A012

P2093

Q24537096-036E14B0-11C0-4BED-BC5E-CACCAAE6C82D

Q24537096-0567CA78-1A97-4E46-AE16-3830BA7E1FF1

Q24537096-192C2F82-2AD3-4B9C-A359-CA7C23429395

Q24537096-4279A198-5876-4B82-8D67-5D26B47644F6

Q24537096-81A1F9DA-8996-49C5-B170-36649888E1FE

Q24537096-85C9289C-D3D3-48C8-AE18-4DA36F2DF141

Q24537096-AFAF68BF-2C7E-4ED7-9159-DD66B2F30E63

P2860

Q24537096-01299C74-4B13-4B09-ADC0-FAB6CDC5A984

Q24537096-0305C766-B4B3-471B-95DA-041E610B275B

Q24537096-04B1CE5B-E25A-402C-AE23-146ED0859B46

Q24537096-06743948-E5E1-41DD-B7B1-078AD4194EA4

Q24537096-0A997D17-C3B7-4A09-A3C8-026CE512754F

Q24537096-0D4F95F1-5AAF-4F2A-92F4-FB04B9E328F2

Q24537096-0ECAD7EC-B0DD-4713-8061-EF9EF3758FFC

Q24537096-111E9368-4B13-4301-BC43-E18384C6BF18

Q24537096-13DD3F84-D365-43E6-A024-327261518522

Q24537096-1C54E3CF-FD2F-4923-A2DA-933F5D8842EC

P304

Q24537096-83967413-DA69-4897-878D-0824745A1FD9

P31

Q24537096-C6C2DFFA-4193-43E3-955E-358FE70CD904

P3181

Q24537096-D80257B7-A181-4A00-B642-8C176ACC63CA

P356

Q24537096-905CA6D3-001C-410F-BB33-0BD96B12180E

P407

Q24537096-110B3D4A-AF7F-4C18-8587-352E6799DA84

P433

Q24537096-E3427EBE-2D4D-402E-9BE4-C786716F83DF

P478

Q24537096-E12F6B3F-71BB-4E35-8B98-5A198A345F2E

P50

Q24537096-49F72B94-FC7B-429F-90DC-FD51EB21D2BD

Q24537096-DE917D58-5639-430A-9E9F-D116CA2E0AD8

P577

Q24537096-ECFF86E2-25DE-4CD0-9B28-14CBD2563AD6

P5875

Q24537096-C2267829-B1C7-4E9F-9410-63965E284B97

P698

Q24537096-A31B9B21-E592-4B04-86FA-199614ED3C23

P921

Q24537096-367EFC54-EEAE-4047-91B4-8BEFF6FE78F3

P932

Q24537096-EFDED7CD-33DC-4164-844C-408ADFE523FF

P3181

P356

SJ.EMBOJ.7600833

P1433

The EMBO Journal

P1476

The translesion DNA polymerase ...... lin gene somatic hypermutation

@en

P2093

Ahmed Al-Qahtani

http://www.w3.org/2001/XMLSchema#string

Albert J Evinger Iii

http://www.w3.org/2001/XMLSchema#string

Hong Zan

http://www.w3.org/2001/XMLSchema#string

John C Schimenti

http://www.w3.org/2001/XMLSchema#string

Naoko Shima

http://www.w3.org/2001/XMLSchema#string

Yuan Zhong

http://www.w3.org/2001/XMLSchema#string

Zhenming Xu

http://www.w3.org/2001/XMLSchema#string

P2860

Eukaryotic DNA Polymerases

High-efficiency bypass of DNA damage by human DNA polymerase Q

Immunity through DNA deamination

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

Class switching and Myc translocation: how does DNA break?

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

P304

3757-3769

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2948369

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/SJ.EMBOJ.7600833

http://www.w3.org/2001/XMLSchema#string

P407

P433

21

http://www.w3.org/2001/XMLSchema#string

P478

24

http://www.w3.org/2001/XMLSchema#string

P50

Paolo Giovanni Casali

Ahmed Al-Qahtani

P577

2005-10-13T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7544582

http://www.w3.org/2001/XMLSchema#string

P698

16222339

http://www.w3.org/2001/XMLSchema#string

P921

Polymerase (DNA directed), theta

P932

1276717

http://www.w3.org/2001/XMLSchema#string