Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. - Wikidata - awgldk - TriplyDB

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

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POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308 The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.Hepatitis C Virus (HCV)-Induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope Protein DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination Polymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.Inaccurate DNA synthesis in cell extracts of yeast producing active human DNA polymerase iota.Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification Genome-wide somatic hypermutation.The chicken as a model for large-scale analysis of vertebrate gene function.Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells.DNA polymerases and somatic hypermutation of immunoglobulin genes Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis.MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1 Involvement of Rad18 in somatic hypermutation The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.Stationary phase mutagenesis: mechanisms that accelerate adaptation of microbial populations under environmental stress.Mismatch-mediated error prone repair at the immunoglobulin genes.Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability.Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity.Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects.DNA deamination in immunity.Expression and possible functions of DNA lesion bypass proteins in spermatogenesis.Analysis of the Par2 modifier of pulmonary adenoma formation in mice.

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Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

http://www.wikidata.org/entity/Q34157224

description

2002 nî lūn-bûn

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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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Induction of somatic hypermuta ...... endent on DNA polymerase iota.

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Induction of somatic hypermuta ...... endent on DNA polymerase iota.

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Induction of somatic hypermuta ...... endent on DNA polymerase iota.

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type

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Induction of somatic hypermuta ...... endent on DNA polymerase iota.

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Induction of somatic hypermuta ...... endent on DNA polymerase iota.

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Induction of somatic hypermuta ...... endent on DNA polymerase iota.

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prefLabel

Induction of somatic hypermuta ...... endent on DNA polymerase iota.

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Induction of somatic hypermuta ...... endent on DNA polymerase iota.

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Induction of somatic hypermuta ...... endent on DNA polymerase iota.

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Induction of somatic hypermuta ...... pendent on DNA polymerase iota

@en

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Ahmad Faili

http://www.w3.org/2001/XMLSchema#string

Claude-Agnès Reynaud

http://www.w3.org/2001/XMLSchema#string

Eric Flatter

http://www.w3.org/2001/XMLSchema#string

Jean-Claude Weill

http://www.w3.org/2001/XMLSchema#string

Quentin Guéranger

http://www.w3.org/2001/XMLSchema#string

P2860

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.

Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

The Y-family of DNA polymerases

Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

An immunoglobulin mutator that targets G.C base pairs.

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10.1038/NATURE01117

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6910

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419

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1043216199

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12410315

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