Physical and functional interactions between PML and MDM2 - Wikidata - awgldk - TriplyDB

Physical and functional interactions between PML and MDM2

Physical and functional interactions between PML and MDM2

http://www.wikidata.org/entity/Q28205380

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PML regulates p53 stability by sequestering Mdm2 to the nucleolus MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53 MG53 regulates membrane budding and exocytosis in muscle cells.Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?Therapeutic considerations for Mdm2: not just a one trick pony Immediate early gene X1 (IEX-1) is organized in subnuclear structures and partially co-localizes with promyelocytic leukemia protein in HeLa cells.PML-mediated signaling and its role in cancer stem cells.Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms.Evidence that the human cytomegalovirus IE2-86 protein binds mdm2 and facilitates mdm2 degradation PML nuclear bodies and apoptosis.PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence.Splicing up mdm2 for cancer proteome diversity.New insights into the role of PML in tumour suppression.Impairment of p53 acetylation, stability and function by an oncogenic transcription factor.Regulation of apoptosis by PML and the PML-NBs.Defective DNA-damage repair induced by nuclear lamina dysfunction is a key mediator of smooth muscle cell aging.Role of the promyelocytic leukaemia protein in cell death regulation.MDM2's social network.TRIMming p53's anticancer activity.Regulation of E2Fs and senescence by PML nuclear bodies.SUMO E3 ligase activity of TRIM proteins.Activation of endogenous p53 by combined p19Arf gene transfer and nutlin-3 drug treatment modalities in the murine cell lines B16 and C6.Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta.The Many Faces of MDM2 Binding Partners.The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation.

P2860

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P2860

Physical and functional interactions between PML and MDM2

http://www.wikidata.org/entity/Q28205380

description

2003 nî lūn-bûn

@nan

2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Physical and functional interactions between PML and MDM2

@ast

Physical and functional interactions between PML and MDM2

@en

Physical and functional interactions between PML and MDM2

@nl

type

label

Physical and functional interactions between PML and MDM2

@ast

Physical and functional interactions between PML and MDM2

@en

Physical and functional interactions between PML and MDM2

@nl

prefLabel

Physical and functional interactions between PML and MDM2

@ast

Physical and functional interactions between PML and MDM2

@en

Physical and functional interactions between PML and MDM2

@nl

P1433

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P2860

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P1433

Journal of Biological Chemistry

P1476

Physical and functional interactions between PML and MDM2

@en

P2093

Arivudainambi Ramalingam

http://www.w3.org/2001/XMLSchema#string

Carl G Maki

http://www.w3.org/2001/XMLSchema#string

Jiang H Yu

http://www.w3.org/2001/XMLSchema#string

Steven R Grossman

http://www.w3.org/2001/XMLSchema#string

Xiaolong Wei

http://www.w3.org/2001/XMLSchema#string

Zhong Kang Yu

http://www.w3.org/2001/XMLSchema#string

P2860

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

Regulation of p53 activity in nuclear bodies by a specific PML isoform

Mdm2 promotes the rapid degradation of p53

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus.

Regulation of p53 stability by Mdm2

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML

Amplification of a gene encoding a p53-associated protein in human sarcomas

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Identification of three major sentrinization sites in PML

The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

P304

29288-29297

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scholarly article

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10.1074/JBC.M212215200

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P433

31

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P478

278

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P577

2003-05-19T00:00:00Z

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12759344

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