Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain
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Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeThe stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathwayActivation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sitesRegulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosisCrystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitorX-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocketStructural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapyStructural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domainFragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylationMDC1 is coupled to activated CHK2 in mammalian DNA damage response pathwaysEDD mediates DNA damage-induced activation of CHK2Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatasePhospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage responseChk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibitionXenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA endsDouble-strand DNA breaks recruit the centromeric histone CENP-A.Chk2 prevents mitotic exit when the majority of kinetochores are unattached.The FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses.NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway.Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometryPph3 dephosphorylation of Rad53 is required for cell recovery from MMS-induced DNA damage in Candida albicans.TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinaseThe co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation.CHK2 kinase in the DNA damage response and beyondCHEK2 contribution to hereditary breast cancer in non-BRCA familiesMolecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenanceRepair of topoisomerase I-mediated DNA damage.Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals.Candidate protein biodosimeters of human exposure to ionizing radiation.CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumoursThe ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cellsReplication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeastCCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.Reconstitution of Rad53 activation by Mec1 through adaptor protein Mrc1.'AND' logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7.Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy.
P2860
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P2860
Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Phosphorylation of threonine 6 ...... the forkhead-associated domain
@ast
Phosphorylation of threonine 6 ...... the forkhead-associated domain
@en
Phosphorylation of threonine 6 ...... the forkhead-associated domain
@nl
type
label
Phosphorylation of threonine 6 ...... the forkhead-associated domain
@ast
Phosphorylation of threonine 6 ...... the forkhead-associated domain
@en
Phosphorylation of threonine 6 ...... the forkhead-associated domain
@nl
prefLabel
Phosphorylation of threonine 6 ...... the forkhead-associated domain
@ast
Phosphorylation of threonine 6 ...... the forkhead-associated domain
@en
Phosphorylation of threonine 6 ...... the forkhead-associated domain
@nl
P2093
P2860
P3181
P356
P1476
Phosphorylation of threonine 6 ...... the forkhead-associated domain
@en
P2093
Christine E Canman
Heather L Davis
Joon-Young Ahn
Xianghong Li
P2860
P304
P3181
P356
10.1074/JBC.M200822200
P407
P577
2002-05-31T00:00:00Z