Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast
about
Activation of the DNA damage checkpoint in mutants defective in DNA replication initiationEsc4/Rtt107 and the control of recombination during replication.Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointRedundant mechanisms prevent mitotic entry following replication arrest in the absence of Cdc25 hyper-phosphorylation in fission yeast.Rif1 is a global regulator of timing of replication origin firing in fission yeast.Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67.Coordination of DNA synthesis and replicative unwinding by the S-phase checkpoint pathways.Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeastHyphal differentiation induced via a DNA damage checkpoint-dependent pathway engaged in crosstalk with nutrient stress signaling in Schizosaccharomyces japonicus.Predicting chemotherapeutic drug combinations through gene network profilingAssays used to study the DNA replication checkpoint in fission yeast.Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.Pcf1, a large subunit of CAF-1, required for maintenance of checkpoint kinase Cds1 activity.Diminished S-phase cyclin-dependent kinase function elicits vital Rad53-dependent checkpoint responses in Saccharomyces cerevisiae.Multiple functions of the S-phase checkpoint mediator.Brc1 links replication stress response and centromere function.Proteasome-dependent degradation of replisome components regulates faithful DNA replicationHsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast.Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation.Involvement of fission yeast Clr6-HDAC in regulation of the checkpoint kinase Cds1.Mrc1/Claspin: a new role for regulation of origin firing.Interactions between Swi1-Swi3, Mrc1 and S phase kinase, Hsk1 may regulate cellular responses to stalled replication forks in fission yeast.Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate.Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase.A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast.Autoinhibition and autoactivation of the DNA replication checkpoint kinase Cds1Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast.The phosphorylation network for efficient activation of the DNA replication checkpoint in fission yeast.Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage responseSap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe.Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1.DNA binding domain in the replication checkpoint protein Mrc1 of Schizosaccharomyces pombe.Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.
P2860
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P2860
Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
@zh-sg
2003年學術文章
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2003年學術文章
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2003年學術文章
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name
Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast
@en
Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast.
@nl
type
label
Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast
@en
Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast.
@nl
prefLabel
Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast
@en
Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast.
@nl
P2093
P2860
P1476
Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast
@en
P2093
Chiaki Nogochi
Eishi Nogochi
Katsunori Tanaka
Paul Russell
P2860
P304
P356
10.1128/MCB.23.22.8395-8403.2003
P407
P577
2003-11-01T00:00:00Z