Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
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TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpainPhysiological and pathological phosphorylation of tau by Cdk5Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-OgnaDown-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brainCyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosisDevelopment and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's diseaseCDK5 activator p35 downregulates E-cadherin precursor independently of CDK5Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephalyCdk5 activity in the brain - multiple paths of regulation.Mechanisms of tau-induced neurodegeneration.Synaptic roles of cyclin-dependent kinase 5 & its implications in epilepsyCDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylationDeveloping pharmacological therapies for Alzheimer disease.Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention.Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis.Negative regulation of cyclin-dependent kinase 5 targets by protein kinase CAdvances in the pathogenesis of Alzheimer's disease: focusing on tau-mediated neurodegeneration.Mechanistic role of calpains in postischemic neurodegeneration.Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity.Oxidized lipoproteins inhibit surfactant phosphatidylcholine synthesis via calpain-mediated cleavage of CTP:phosphocholine cytidylyltransferase.Special Issue on "Cdk5 and Brain Disorders": PrologueCyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulationAMP-activated protein kinase: a potential player in Alzheimer's disease.Role of cell cycle re-entry in neurons: a common apoptotic mechanism of neuronal cell death.Sumoylation of p35 modulates p35/cyclin-dependent kinase (Cdk) 5 complex activity.Cdk5 links with DNA damage response and cancer.Cdk5--p39 is a labile complex with the similar substrate specificity to Cdk5--p35.Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: identification of 3' substituted indolones as a scaffold for the development of neuroprotective drugs.Targeting Cdk5 activity in neuronal degeneration and regeneration.Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator.Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons.Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia.[EXPRESS] Peripheral and orofacial pain sensation is unaffected by the loss of p39.N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation.Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke.Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules.Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1.Involvement of cyclin-dependent kinase-5 in the kainic acid-mediated degeneration of glutamatergic synapses in the rat hippocampus.Profiling of p5, a 24 Amino Acid Inhibitory Peptide Derived from the CDK5 Activator, p35 CDKR1 Against 70 Protein Kinases.Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis
P2860
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P2860
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
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2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
@ast
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
@en
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
@nl
type
label
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
@ast
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
@en
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
@nl
prefLabel
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
@ast
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
@en
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
@nl
P2860
P356
P1476
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
@en
P2093
Holger Patzke
Li-Huei Tsai
P2860
P304
P356
10.1074/JBC.M109645200
P407
P577
2002-03-08T00:00:00Z