Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis - Wikidata - awgldk - TriplyDB

Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis

Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis

http://www.wikidata.org/entity/Q57834817

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The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide Mitochondrial biology and Parkinson's disease Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease Calcium channel blockers and Alzheimer's disease Mitochondrial dysfunction and oxidative stress in Parkinson's disease Mitochondrial fragmentation in neurodegeneration The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition.Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis.CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies.The role of Cdk5 in cognition and neuropsychiatric and neurological pathology.Phosphoproteomic analysis of protein phosphorylation networks in Tetrahymena thermophila, a model single-celled organism.Down-regulation of mortalin exacerbates Aβ-mediated mitochondrial fragmentation and dysfunction.Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila Peptide TFP5/TP5 derived from Cdk5 activator P35 provides neuroprotection in the MPTP model of Parkinson's disease.Genetic Control over mtDNA and Its Relationship to Major Depressive Disorder.Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology.The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention.Activated cyclin-dependent kinase 5 promotes microglial phagocytosis of fibrillar β-amyloid by up-regulating lipoprotein lipase expression Nitric oxide in health and disease of the nervous system.Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP Emerging roles of mitochondrial membrane dynamics in health and disease.S-nitrosation and ubiquitin-proteasome system interplay in neuromuscular disorders.Abnormal mitochondrial dynamics and neurodegenerative diseases.Inhibitors of mitochondrial fission as a therapeutic strategy for diseases with oxidative stress and mitochondrial dysfunction.Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease?Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration.Emerging role of protein-protein transnitrosylation in cell signaling pathways.Programmed cell death in Parkinson's disease Sumoylation in neurodegenerative diseases.Water-Soluble Coenzyme Q10 Reduces Rotenone-Induced Mitochondrial Fission.SUMO-regulated mitochondrial function in Parkinson's disease.

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Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis

http://www.wikidata.org/entity/Q57834817

description

im Januar 2007 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 12 January 2007

@en

wetenschappelijk artikel

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наукова стаття, опублікована в січні 2007

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name

Cyclin-dependent kinase 5 is a ...... sion during neuronal apoptosis

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Cyclin-dependent kinase 5 is a ...... sion during neuronal apoptosis

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type

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Cyclin-dependent kinase 5 is a ...... sion during neuronal apoptosis

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Cell Death & Differentiation

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Cyclin-dependent kinase 5 is a ...... sion during neuronal apoptosis

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B Göricke

http://www.w3.org/2001/XMLSchema#string

G P H Dietz

http://www.w3.org/2001/XMLSchema#string

I E Suppanz

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J H Weishaupt

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K Meuer

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L Fichtner

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M Bähr

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V Planchamp

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The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology

hFis1, a novel component of the mammalian mitochondrial fission machinery

Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29

Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death

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651-661

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scholarly article

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10.1038/SJ.CDD.4402087

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4

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14

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Gerhard H Braus

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2007-01-12T00:00:00Z

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1005640602

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17218957

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