about
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylationCyclin Y, a novel membrane-associated cyclin, interacts with PFTK1Biochemical characterization of Cdk2-Speedy/Ringo A2.Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsPhysiological and pathological phosphorylation of tau by Cdk5Structure of the Pho85-Pho80 CDK-Cyclin Complex of the Phosphate-Responsive Signal Transduction PathwayThe structure of CDK4/cyclin D3 has implications for models of CDK activationNew Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate RecognitionThe neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cellsCalpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29Molecular basis of differential selectivity of cyclobutyl-substituted imidazole inhibitors against CDKs: insights for rational drug designEffects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociationSurface comparison of active and inactive protein kinases identifies a conserved activation mechanismCharacterization of a new family of cyclin-dependent kinase activators.A specific interaction between muskelin and the cyclin-dependent kinase 5 activator p39 promotes peripheral localization of muskelin.The CDK5 activator, p39, binds specifically to myosin essential light chain.Cdk5 activity in the brain - multiple paths of regulation.An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylationPotential role of microsomal prostaglandin E synthase-1 in tumorigenesis.At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology.CDK5 activator protein p25 preferentially binds and activates GSK3βDiscovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screeningSelectivity and potency of cyclin-dependent kinase inhibitors.Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors.Cycling at the interface between neurodevelopment and neurodegeneration.Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formationDetection and characterization of nonspecific, sparsely populated binding modes in the early stages of complexation.Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan.A CDK-related kinase regulates the length and assembly of flagella in Chlamydomonas.Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.Orphan kinases turn eccentric: a new class of cyclin Y-activated, membrane-targeted CDKsp10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicityPosttranslational modification of the androgen receptor in prostate cancer.Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.Cdk5 and the non-catalytic arrest of the neuronal cell cycle.Computational study of the inhibitory mechanism of the kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore.The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structure and regulation of the CDK5-p25(nck5a) complex
@ast
Structure and regulation of the CDK5-p25(nck5a) complex
@en
Structure and regulation of the CDK5-p25(nck5a) complex
@nl
type
label
Structure and regulation of the CDK5-p25(nck5a) complex
@ast
Structure and regulation of the CDK5-p25(nck5a) complex
@en
Structure and regulation of the CDK5-p25(nck5a) complex
@nl
prefLabel
Structure and regulation of the CDK5-p25(nck5a) complex
@ast
Structure and regulation of the CDK5-p25(nck5a) complex
@en
Structure and regulation of the CDK5-p25(nck5a) complex
@nl
P2093
P1433
P1476
Structure and regulation of the CDK5-p25(nck5a) complex
@en
P2093
P304
P356
10.1016/S1097-2765(01)00343-4
P407
P577
2001-09-01T00:00:00Z