Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate - Wikidata - awgldk - TriplyDB

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

http://www.wikidata.org/entity/Q28239967

about

Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling Structural basis of substrate discrimination and integrin binding by autotaxin Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations Autotaxin: structure-function and signaling A metabolically-stabilized phosphonate analog of lysophosphatidic acid attenuates collagen-induced arthritis An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors.Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX).Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.Inhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three-dimensional lung cancer xenograft model.Cellular function and molecular structure of ecto-nucleotidases.Aiming drug discovery at lysophosphatidic acid targets.Effects of gintonin on the proliferation, migration, and tube formation of human umbilical-vein endothelial cells: involvement of lysophosphatidic-acid receptors and vascular-endothelial-growth-factor signaling.Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution Lysophosphatidic Acid signaling in the nervous system.Ligand-based autotaxin pharmacophore models reflect structure-based docking results.Phospholipase D: enzymology, functionality, and chemical modulation Chemical evolution of autotaxin inhibitors Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma.Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.The tumor microenvironment: key to early detection.Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis.Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity Lysophospholipid interactions with protein targets.Autotaxin (ATX): a multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties Cyclic phosphatidic acid - a unique bioactive phospholipid.Phosphatase-resistant analogues of lysophosphatidic acid: agonists promote healing, antagonists and autotaxin inhibitors treat cancer.Therapeutic potential of autotaxin/lysophospholipase d inhibitors.Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis Lipid phosphate phosphatases and signaling.Autotaxin structure-activity relationships revealed through lysophosphatidylcholine analogs.

P2860

Q21245736-0A8E88B6-BAE7-42E9-8307-DFF4E3733509 Q24337236-BDC4DF33-3F14-49F1-8046-3245B11F44F4 Q28260852-DD9D2640-B2FA-4671-8D8D-832CCA73F1A5 Q28286551-F1AE5C66-642D-437A-8906-C5765775EBE9 Q28307790-14A67D7D-2A4D-4E57-9C63-8927F0AAC8DE Q28534911-242EB3AE-276F-49EE-9C11-6565A07105F4 Q28577987-C4C3E9E8-9042-427A-9022-761CFFA74750 Q30408519-82E1BF74-FB4A-41C9-AA97-1F657194FD7C Q30411650-3D259960-9992-422F-908D-6DCE98032EEF Q30429428-B71130FA-052C-4921-8919-D2FD3D9CED46 Q30434740-C86013C9-7DD5-4F58-89E8-B676DBD387F1 Q33548625-460E9D7A-2E89-43A6-A20D-88D73292AC98 Q33759458-CD7910AA-B342-4EBF-8911-EB94EFD8106C Q34031794-0E3F7EA4-F602-47A3-B03F-4A3CDBC50AFD Q34339759-5EE38472-2969-4060-85C8-D36A70EDC7F1 Q34542721-BFCD1955-CCA6-4B9D-86E7-A50DFE13670F Q34580111-9E0BB3C3-88BA-4B34-B413-B46EFDCE8E29 Q34769231-66D15EA1-4A04-4472-8060-57454B0435C3 Q35118841-CD117448-2921-448F-841E-B858C5070DF6 Q35314358-D087E0CB-B8DB-42AA-8224-C1A4FB06A23F Q35456340-397482C4-FA4F-44CD-8BC0-44479DA82951 Q35575527-A3BAADE6-05A0-4A54-9A4A-674A3E8DBA7E Q35599714-C2727AA0-01BB-4995-B789-8E20D88F9B71 Q35949924-3D4656BE-AD9C-4479-BC43-B40AAB9C66F5 Q36011319-EE54657B-7BF1-4C37-8C7A-9187ED18E95F Q36246828-E328C62F-6594-4F1D-8E00-A36E1B0AF6DF Q36246895-10DE6A87-31EC-4154-8AE0-91519069FA56 Q36421116-B5128F30-53FB-4E26-96C5-285BAAAE6119 Q36452780-4D065A4D-097D-4037-B873-9648E8A5C103 Q36627750-D0F654B7-8EED-420C-B159-7B66E33C263A Q36664243-4006778C-4155-4485-A444-08752D23EB6C Q36861053-A3ABE843-C6D2-4FD1-91A6-1B66A9CEB382 Q36930850-16113631-3278-4FCA-BAFF-46B4C4281E32 Q36930924-B78F297C-EA6C-4EEB-9C05-AF6BE8217B0F Q36947041-FA02B8F5-8646-472A-AA16-E1E5640E2C20 Q37003428-3A11B689-CD1D-49A0-9A00-5D0016ED6F5C Q37049044-5E5E2DA4-2398-4801-B5D1-11737344990C Q37119757-8C18E50A-9AA4-40EA-98C6-28C4CE4B88B7 Q37173179-3CDBA161-605C-4131-A386-4060023C075F Q37250907-FDE53158-E961-4C77-B66C-2A51F6364516

P2860

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

http://www.wikidata.org/entity/Q28239967

description

2005 nî lūn-bûn

@nan

2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

@ast

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

@en

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

@nl

type

label

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

@ast

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

@en

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

@nl

prefLabel

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

@ast

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

@en

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

@nl

P1433

Q28239967-FBDF6579-C1EA-47A6-B35E-A97D81E9BC2B

P1476

Q28239967-E65EECB4-CB2C-44AE-9DEE-90EB5126AF8B

P2093

Q28239967-8D0CFCC8-25B6-4957-B583-3AA0CCDC0098

Q28239967-A9C65420-EB3B-477A-91A9-E654C666BDE7

Q28239967-AED53D2E-2F44-488D-8476-5F42E72B0A34

Q28239967-B206C8AC-2619-4249-8483-72480BF48316

Q28239967-F27BDD7C-B18E-4B15-9497-616A3FA78D6E

Q28239967-FA0C8333-06FF-4ADA-BF97-3207B059A752

P2860

Q28239967-1EE394FC-B32F-46FA-871A-16EAD364ADCE

Q28239967-27E2662A-F18D-417E-8A9A-DED0A8B1EE92

Q28239967-2C97BCA7-8413-473C-A4B8-7704AB6612EC

Q28239967-33E5E7E9-7E1D-4A70-A154-FEEA13229488

Q28239967-343401CD-0BC6-4A63-8193-0C1A7DC41012

Q28239967-3BEE8F5A-24CD-454E-801B-5ED9DC6ADF89

Q28239967-3C9D429C-410B-49D7-8C98-79DFC2E028B1

Q28239967-440C6692-41BE-4C0F-AA4C-0CA00A09D775

Q28239967-53F94266-ABB1-4038-8572-13E82D1AB065

Q28239967-63D62475-2A81-402C-B552-67C8F542E8E6

P304

Q28239967-A53116C6-C04A-4C61-AD97-0E8A9243455A

P31

Q28239967-A1DA830E-F4B1-45C8-99B1-B85104F20574

P356

Q28239967-015A66B5-D2E5-4588-9EFB-B5BA4DD4184F

P407

Q28239967-84D196A4-866A-48EE-B1AA-7E0DA0D597FA

P433

Q28239967-58496EA4-255F-4414-96DB-5284F0CB13CF

P478

Q28239967-AFB9A89A-C79A-42A7-89B4-86898527FB37

P50

Q28239967-446D056D-6A72-418A-9707-B91F679CD55F

Q28239967-C2C7AC3A-B34B-4091-BFF1-778ADDB1E0AE

Q28239967-D46283F4-C0E7-455C-9127-D25E4EDAC73E

P577

Q28239967-88C0D802-42D0-4FA7-93CE-DEC16320F6E6

P698

Q28239967-1C3B8FDF-CA88-4A92-AD73-8A388FD7343E

P356

P1433

Journal of Biological Chemistry

P1476

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

@en

P2093

Hideo Takakusa

http://www.w3.org/2001/XMLSchema#string

James W Goding

http://www.w3.org/2001/XMLSchema#string

Kazuya Kikuchi

http://www.w3.org/2001/XMLSchema#string

Paula Ruurs

http://www.w3.org/2001/XMLSchema#string

Tetsuo Nagano

http://www.w3.org/2001/XMLSchema#string

Wouter H Moolenaar

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of plasma unsaturated lysophosphatidylcholines in human and rat

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site

The emerging role of lysophosphatidic acid in cancer

Lysophospholipids--receptor revelations

Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase

Stimulation of tumor cell motility linked to phosphodiesterase catalytic site of autotaxin

Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities

Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors

Developmental expression analysis of murine autotaxin (ATX)

P304

21155-61

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M413183200

http://www.w3.org/2001/XMLSchema#string

P407

P433

22

http://www.w3.org/2001/XMLSchema#string

P478

280

http://www.w3.org/2001/XMLSchema#string

P50

Anastassis Perrakis

Laurens A van Meeteren

Evangelos Christodoulou

P577

2005-06-03T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15769751

http://www.w3.org/2001/XMLSchema#string