Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities
about
PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcificationFunctional studies of human intestinal alkaline sphingomyelinase by deglycosylation and mutagenesisFunctional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid productionL-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxinA superfamily of metalloenzymes unifies phosphopentomutase and cofactor-independent phosphoglycerate mutase with alkaline phosphatases and sulfatasesInhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphateRat liver nucleotide pyrophosphatase/phosphodiesterase is an efficient adenylyl transferaseIL-1 beta- and IL-4-induced down-regulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA)The heterotrimeric G protein subunits Gα(q) and Gβ(1) have lysophospholipase D activityStructural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatasesCancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclastsNovel point mutations attenuate autotaxin activityConserved core structure and active site residues in alkaline phosphatase superfamily enzymes.Survey of phosphorylation near drug binding sites in the Protein Data Bank (PDB) and their effects.An iron-dependent bacterial phospholipase D reminiscent of purple acid phosphatases.Purification, cloning, and expression of an apyrase from the bed bug Cimex lectularius. A new type of nucleotide-binding enzyme.Cellular function and molecular structure of ecto-nucleotidases.Stat3 mediates expression of autotaxin in breast cancerConstitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin.Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distributionSite-directed mutagenesis maps interactions that enhance cognate and limit promiscuous catalysis by an alkaline phosphatase superfamily phosphodiesterase.Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesityAutotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progressionCarba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasisPhosphodiesterase-Ialpha/autotaxin's MORFO domain regulates oligodendroglial process network formation and focal adhesion organization.Autotaxin (ATX): a multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular propertiesTherapeutic potential of autotaxin/lysophospholipase d inhibitors.Lysophosphatidic acid signaling in airway epithelium: role in airway inflammation and remodeling.Autotaxin: its role in biology of melanoma cells and as a pharmacological target.Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells.Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin InhibitorFowlpox virus encodes nonessential homologs of cellular alpha-SNAP, PC-1, and an orphan human homolog of a secreted nematode proteinMeganuclease-driven targeted integration in CHO-K1 cells for the fast generation of HTS-compatible cell-based assays.Autotaxin promotes the expression of matrix metalloproteinase-3 via activation of the MAPK cascade in human fibrosarcoma HT-1080 cells.Lysophospholipid signaling: beyond the EDGs.Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells.Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells.Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during developmentThe biochemistry of cancer dissemination.
P2860
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P2860
Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Autotaxin is an exoenzyme poss ...... sphatase and ATPase activities
@ast
Autotaxin is an exoenzyme poss ...... sphatase and ATPase activities
@en
Autotaxin is an exoenzyme poss ...... sphatase and ATPase activities
@nl
type
label
Autotaxin is an exoenzyme poss ...... sphatase and ATPase activities
@ast
Autotaxin is an exoenzyme poss ...... sphatase and ATPase activities
@en
Autotaxin is an exoenzyme poss ...... sphatase and ATPase activities
@nl
prefLabel
Autotaxin is an exoenzyme poss ...... sphatase and ATPase activities
@ast
Autotaxin is an exoenzyme poss ...... sphatase and ATPase activities
@en
Autotaxin is an exoenzyme poss ...... sphatase and ATPase activities
@nl
P2093
P2860
P356
P1476
Autotaxin is an exoenzyme poss ...... sphatase and ATPase activities
@en
P2093
P2860
P304
P356
10.1074/JBC.272.2.996
P407
P577
1997-01-10T00:00:00Z