Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.
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Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine ReceptorsZinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol.Altered sedative effects of ethanol in mice with α1 glycine receptor subunits that are insensitive to Gβγ modulationMutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivoA point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.Molecular targets and mechanisms for ethanol action in glycine receptorsIvermectin antagonizes ethanol inhibition in purinergic P2X4 receptorsA transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.Control of ethanol sensitivity of the glycine receptor α3 subunit by transmembrane 2, the intracellular splice cassette and C-terminal domains.Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofolMolecular determinants of ivermectin sensitivity at the glycine receptor chloride channelThe TM2 6' position of GABA(A) receptors mediates alcohol inhibitionCharge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptorsSubunit stoichiometry and arrangement in a heteromeric glutamate-gated chloride channel.Intermediate closed state for glycine receptor function revealed by cysteine cross-linking.Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation.Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.Additional acetylcholine (ACh) binding site at alpha4/alpha4 interface of (alpha4beta2)2alpha4 nicotinic receptor influences agonist sensitivity.Mechanism of Allosteric Modulation of the Cys-loop Receptors.Probing pore constriction in a ligand-gated ion channel by trapping a metal ion in the pore upon agonist dissociation.Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization.Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors.Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Allosteric Modulation of αβδ GABAA Receptors.Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.
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Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Loop 2 structure in glycine and GABA
@nl
Loop 2 structure in glycine an ...... termining ethanol sensitivity.
@en
type
label
Loop 2 structure in glycine and GABA
@nl
Loop 2 structure in glycine an ...... termining ethanol sensitivity.
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prefLabel
Loop 2 structure in glycine and GABA
@nl
Loop 2 structure in glycine an ...... termining ethanol sensitivity.
@en
P2093
P2860
P356
P1476
Loop 2 structure in glycine an ...... termining ethanol sensitivity.
@en
P2093
Daniel K Crawford
Daryl L Davies
Daya I Perkins
James R Trudell
Liana Asatryan
Ronald L Alkana
P2860
P304
27304-27314
P356
10.1074/JBC.M109.023598
P407
P577
2009-08-05T00:00:00Z