Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer
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LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivoLoss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneityHigh rates of loss of heterozygosity on chromosome 19p13 in human breast cancerGermline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancersGenes other than BRCA1 and BRCA2 involved in breast cancer susceptibilitySTK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreasSpectrum of LKB1, EGFR, and KRAS mutations in chinese lung adenocarcinomas.No association between promoter polymorphism of STK11 gene and lung cancer risk in the Korean population.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients.Mutational analysis of STK11 gene in ovarian carcinomas.Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrestSomatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndromePeutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinomaFurther observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma.5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer.Cancer risks in LKB1 germline mutation carriers.Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrityLKB1 somatic mutations in sporadic tumors.Prevalence and specificity of LKB1 genetic alterations in lung cancersUnderexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma.Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer.LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteinsLKB1 catalytic activity contributes to estrogen receptor alpha signalingDysregulation of mTOR activity through LKB1 inactivation.Germinal center kinases in immune regulation.Methylation of STK11 promoter is a risk factor for tumor stage and survival in clear cell renal cell carcinoma.Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome.PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1.Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability.
P2860
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P2860
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Low frequency of somatic mutat ...... gene in sporadic breast cancer
@ast
Low frequency of somatic mutat ...... gene in sporadic breast cancer
@en
Low frequency of somatic mutat ...... gene in sporadic breast cancer
@nl
type
label
Low frequency of somatic mutat ...... gene in sporadic breast cancer
@ast
Low frequency of somatic mutat ...... gene in sporadic breast cancer
@en
Low frequency of somatic mutat ...... gene in sporadic breast cancer
@nl
prefLabel
Low frequency of somatic mutat ...... gene in sporadic breast cancer
@ast
Low frequency of somatic mutat ...... gene in sporadic breast cancer
@en
Low frequency of somatic mutat ...... gene in sporadic breast cancer
@nl
P2093
P1433
P1476
Low frequency of somatic mutat ...... gene in sporadic breast cancer
@en
P2093
P304
P407
P577
1998-04-01T00:00:00Z