Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers - Wikidata - awgldk - TriplyDB

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers

http://www.wikidata.org/entity/Q24671334

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ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas Genetic abnormalities in pancreatic cancer Genetic alterations in pancreatic carcinoma Clinical Genetic Testing in Gastroenterology Early detection and prevention of pancreatic cancer: is it really possible today?Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing.Genetic factors affecting patient responses to pancreatic cancer treatment A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366 Pancreatic cancer.LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.[Early pancreatic cancer: can the methods currently available identify this disease?].Intraductal papillary mucinous neoplasms of the pancreas: is the puzzle solved?Importance of age of onset in pancreatic cancer kindreds Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.Pancreatic cancer genomics: insights and opportunities for clinical translation Epigenetics and pancreatic cancer: pathophysiology and novel treatment aspects Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma.Precursor lesions of pancreatic cancer.Molecular signatures of pancreatic cancer.Inherited predisposition to pancreatic cancer.Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas.EZH2 couples pancreatic regeneration to neoplastic progression.Cystic lesions of the pancreas.The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome.LKB1, a protein kinase regulating cell proliferation and polarity.STRAD in Peutz-Jeghers syndrome and sporadic cancers.Prediction of disease-related genes based on weighted tissue-specific networks by using DNA methylation Genetics and pathology of pancreatic cancer.Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project.Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010.Molecular pathways in pancreatic carcinogenesis Biology and management of pancreatic cancer.LKB1 preserves genome integrity by stimulating BRCA1 expression.Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer

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Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers

http://www.wikidata.org/entity/Q24671334

description

1999 nî lūn-bûn

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1999 թուականի Յունիսին հրատարակուած գիտական յօդուած

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1999 թվականի հունիսին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

Germline and somatic mutations ...... pancreatic and biliary cancers

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Germline and somatic mutations ...... pancreatic and biliary cancers

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Germline and somatic mutations ...... pancreatic and biliary cancers

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label

Germline and somatic mutations ...... pancreatic and biliary cancers

@ast

Germline and somatic mutations ...... pancreatic and biliary cancers

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Germline and somatic mutations ...... pancreatic and biliary cancers

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Germline and somatic mutations ...... pancreatic and biliary cancers

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Germline and somatic mutations ...... pancreatic and biliary cancers

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Germline and somatic mutations ...... pancreatic and biliary cancers

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The American Journal of Pathology

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Germline and somatic mutations ...... pancreatic and biliary cancers

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A M Westerman

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C J Yeo

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D J Tang

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G H Su

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G S Bova

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M C Shekher

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M Goggins

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M M Entius

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R H Hruban

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R K Bansal

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P2860

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer

Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region.

Increased risk for cancer in patients with the Peutz-Jeghers syndrome.

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1835-40

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