Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets - Wikidata - awgldk - TriplyDB

Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets

Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets

http://www.wikidata.org/entity/Q28283796

about

Computational redesign of endonuclease DNA binding and cleavage specificity Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences Catalytic domain of restriction endonuclease BmrI as a cleavage module for engineering endonucleases with novel substrate specificities Homing endonuclease I-CreI derivatives with novel DNA target specificities In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination Progress and prospects of engineered sequence-specific DNA modulating technologies for the management of liver diseases Homing endonucleases: DNA scissors on a mission Current translational and clinical practices in hematopoietic cell and gene therapy The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage Crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus Evolution of I-SceI Homing Endonucleases with Increased DNA Recognition Site Specificity 5'-Cytosine-Phosphoguanine (CpG) Methylation Impacts the Activity of Natural and Engineered Meganucleases Non-specific protein-DNA interactions control I-CreI target binding and cleavage BuD, a helix-loop-helix DNA-binding domain for genome modification.Visualizing phosphodiester-bond hydrolysis by an endonuclease Biology by design: reduction and synthesis of cellular components and behaviour A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI.Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences.Germline-transmitted genome editing in Arabidopsis thaliana Using TAL-effector-nucleases.Phylogenetic screening of a bacterial, metagenomic library using homing endonuclease restriction and marker insertion.Gene correction by homologous recombination with zinc finger nucleases in primary cells from a mouse model of a generic recessive genetic disease.Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases.Using protein design algorithms to understand the molecular basis of disease caused by protein-DNA interactions: the Pax6 example.Comprehensive analysis of the specificity of transcription activator-like effector nucleases.Improved soybean oil quality by targeted mutagenesis of the fatty acid desaturase 2 gene family.Optimized tuning of TALEN specificity using non-conventional RVDs.Targeted DNA excision in Arabidopsis by a re-engineered homing endonuclease Meganuclease-mediated Inhibition of HSV1 Infection in Cultured Cells.Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering.Highly specific contractions of a single CAG/CTG trinucleotide repeat by TALEN in yeast.Efficient design of meganucleases using a machine learning approach.Exploring the transcription activator-like effectors scaffold versatility to expand the toolbox of designer nucleases.Homing endonucleases: from genetic anomalies to programmable genomic clippers Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy.

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Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets

http://www.wikidata.org/entity/Q28283796

description

2006 nî lūn-bûn

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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2006 թվականի հունվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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name

Engineering of large numbers o ...... mbination on novel DNA targets

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Engineering of large numbers o ...... mbination on novel DNA targets

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Engineering of large numbers o ...... mbination on novel DNA targets

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Engineering of large numbers o ...... mbination on novel DNA targets

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Engineering of large numbers o ...... mbination on novel DNA targets

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Engineering of large numbers o ...... mbination on novel DNA targets

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Engineering of large numbers o ...... mbination on novel DNA targets

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Amélie Patin

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Anne-Sophie Petit

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Aymeric Duclert

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Christophe Perez

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Emmanuel Lacroix

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François Stricher

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Frédéric Pâques

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Guillermo Montoya

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Jesús Prieto

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Francisco J. Blanco

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