Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity - Wikidata - awgldk - TriplyDB

Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity

Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity

http://www.wikidata.org/entity/Q28287994

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Why Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap.Investigations into the Sarcomeric Protein and Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus).Genotype-specific pathogenic effects in human dilated cardiomyopathy.Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin I OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency.Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress 2-Deoxyadenosine triphosphate restores the contractile function of cardiac myofibril from adult dogs with naturally occurring dilated cardiomyopathy.Uncoupling of myofilament Ca2+ sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate.Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation.TPM3 deletions cause a hypercontractile congenital muscle stiffness phenotype.Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants-Genotype to Cellular Phenotype.A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.Myofilament dysfunction as an emerging mechanism of volume overload heart failure.Maladaptive modifications in myofilament proteins and triggers in the progression to heart failure and sudden death.Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies.Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice.Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy.Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes.Long-Term Biased β-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy.Troponin structure: its modulation by Ca(2+) and phosphorylation studied by molecular dynamics simulations.Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.Molecular Defects in Cardiac Myofilament Ca2+-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin.

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P2860

Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity

http://www.wikidata.org/entity/Q28287994

description

2013 nî lūn-bûn

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2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հուլիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Familial dilated cardiomyopath ...... myofibrillar Ca²⁺ sensitivity

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Familial dilated cardiomyopath ...... myofibrillar Ca²⁺ sensitivity

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Familial dilated cardiomyopath ...... myofibrillar Ca²⁺ sensitivity

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type

label

Familial dilated cardiomyopath ...... myofibrillar Ca²⁺ sensitivity

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Familial dilated cardiomyopath ...... myofibrillar Ca²⁺ sensitivity

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Familial dilated cardiomyopath ...... myofibrillar Ca²⁺ sensitivity

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prefLabel

Familial dilated cardiomyopath ...... myofibrillar Ca²⁺ sensitivity

@ast

Familial dilated cardiomyopath ...... myofibrillar Ca²⁺ sensitivity

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Familial dilated cardiomyopath ...... myofibrillar Ca²⁺ sensitivity

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Cardiovascular Research

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Familial dilated cardiomyopath ...... myofibrillar Ca²⁺ sensitivity

@en

P2093

Andrew E Messer

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Cristobal dos Remedios

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Elyshia McNamara

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Gianina Ravenscroft

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Kristen J Nowak

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Lianfeng Zhang

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Man-Ching Leung

http://www.w3.org/2001/XMLSchema#string

Massimiliano Memo

http://www.w3.org/2001/XMLSchema#string

Steven B Marston

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P2860

Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy

Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype

Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro

Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin

Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy

Regulation of cardiac contractile function by troponin I phosphorylation

Phosphate-binding tag, a new tool to visualize phosphorylated proteins

Truncations of titin causing dilated cardiomyopathy.

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65-73

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3336158

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10.1093/CVR/CVT071

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1

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99

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Douglas G. Ward

Sachio Morimoto

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2013-03-27T00:00:00Z

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236090931

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23539503

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phosphorylation