Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A
about
The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial functionStructural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor designTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsStructure of the cyclin-dependent kinase inhibitor p19Ink4dGankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasomeEvaluation of the use of therapeutic peptides for cancer treatmentFunctional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information.Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity.Molecular mechanism of G1 arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells.The identification of unique serum proteins of HIV-1 latently infected long-term non-progressor patients.Homeodomain-derived peptides. In and out of the cells.A new functional classification of tumor-suppressing genes and its therapeutic implications.Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model.Targeting the cell cycle for cancer therapy.A Bovine Lymphosarcoma Cell Line Infected with Theileria annulata Exhibits an Irreversible Reconfiguration of Host Cell Gene Expression.A novel cellular senescence gene, SENEX, is involved in peripheral regulatory T cells accumulation in aged urinary bladder cancerPeptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors.Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonistsPeptides with anticancer use or potential.Molecular neuro-oncology and the development of targeted therapeutic strategies for brain tumors. Part 5: apoptosis and cell cycle.The therapeutic potential of targeting the cell cycle.Familial melanoma-associated mutations in p16 uncouple its tumor-suppressor functionsThe CDK inhibitors: potential targets for therapeutic stem cell manipulations?Therapeutic peptides for cancer therapy. Part II - cell cycle inhibitory peptides and apoptosis-inducing peptides.Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.Modulation of cell proliferation by cytokeratins K10 and K16C-terminal domain of p16(INK4a) is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT-1080 fibrosarcoma cells.Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells.Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.p53 is phosphorylated at the carboxyl terminus and promotes the differentiation of human HaCaT keratinocytes.PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.p16INK4 mediates contact-inhibition of growth.Gene knockout and transgenic technologies in risk assessment: the next generation.Simulation of different truncated p16(INK4a) forms and in silico study of interaction with Cdk4.Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4.Antennapedia/HS1 chimeric phosphotyrosyl peptide: conformational properties, binding capability to c-Fgr SH2 domain and cell permeability.CDK4 expression in chordoma: A potential therapeutic target.Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts.
P2860
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P2860
Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Inhibition of pRb phosphorylat ...... de derived from p16CDKN2/INK4A
@ast
Inhibition of pRb phosphorylat ...... de derived from p16CDKN2/INK4A
@en
Inhibition of pRb phosphorylat ...... de derived from p16CDKN2/INK4A
@nl
type
label
Inhibition of pRb phosphorylat ...... de derived from p16CDKN2/INK4A
@ast
Inhibition of pRb phosphorylat ...... de derived from p16CDKN2/INK4A
@en
Inhibition of pRb phosphorylat ...... de derived from p16CDKN2/INK4A
@nl
prefLabel
Inhibition of pRb phosphorylat ...... de derived from p16CDKN2/INK4A
@ast
Inhibition of pRb phosphorylat ...... de derived from p16CDKN2/INK4A
@en
Inhibition of pRb phosphorylat ...... de derived from p16CDKN2/INK4A
@nl
P2093
P1433
P1476
Inhibition of pRb phosphorylat ...... de derived from p16CDKN2/INK4A
@en
P2093
P356
10.1016/S0960-9822(02)00425-6
P407
P577
1996-01-01T00:00:00Z