Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4.
about
Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsResistance and gain-of-resistance phenotypes in cancers harboring wild-type p53p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer CellsSelectivity and potency of cyclin-dependent kinase inhibitors.Small-molecule cyclin-dependent kinase modulators.Pharmacogenetic candidate genes for melanoma.Cellular senescence in cancer treatment: friend or foe?Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents.Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence.The A-type cyclins and the meiotic cell cycle in mammalian male germ cells.Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerizationDual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein.Cyclin-dependent kinase 2 phosphorylates s/t-p sites in the hepadnavirus core protein C-terminal domain and is incorporated into viral capsids.Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer.Five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs.p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.Functional interplay between the cell cycle and cell phenotypes.Cytotoxic effects of fascaplysin against small cell lung cancer cell lines.Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).γ-Oryzanol reduces caveolin-1 and PCGEM1 expression, markers of aggressiveness in prostate cancer cell lines.A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS.Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27(Kip1) association with cyclin E-Cdk2.Loop flexibility and solvent dynamics as determinants for the selective inhibition of cyclin-dependent kinase 4: comparative molecular dynamics simulation studies of CDK2 and CDK4.Q58648366
P2860
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P2860
Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Selective in vivo and in vitro ...... of cyclin-dependent kinase 4.
@en
Selective in vivo and in vitro ...... of cyclin-dependent kinase 4.
@nl
type
label
Selective in vivo and in vitro ...... of cyclin-dependent kinase 4.
@en
Selective in vivo and in vitro ...... of cyclin-dependent kinase 4.
@nl
prefLabel
Selective in vivo and in vitro ...... of cyclin-dependent kinase 4.
@en
Selective in vivo and in vitro ...... of cyclin-dependent kinase 4.
@nl
P2093
P2860
P356
P1476
Selective in vivo and in vitro ...... of cyclin-dependent kinase 4.
@en
P2093
B Chaudhuri
S Zumstein-Mecker
T O'Reilly
P2860
P304
P356
10.1093/JNCI/93.6.436
P407
P577
2001-03-01T00:00:00Z