The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51 - Wikidata - awgldk - TriplyDB

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

http://www.wikidata.org/entity/Q24323065

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Human single-stranded DNA binding proteins are essential for maintaining genomic stability Purified human BRCA2 stimulates RAD51-mediated recombination A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor An alternative form of replication protein a expressed in normal human tissues supports DNA repair Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2 Using a Fragment-Based Approach To Target Protein-Protein Interactions High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy.Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51 Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins Molding BRCA2 function through its interacting partners Unraveling the mechanism of BRCA2 in homologous recombination Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination Rad52 inactivation is synthetically lethal with BRCA2 deficiency Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination RecO protein initiates DNA recombination and strand annealing through two alternative DNA binding mechanisms.The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques.Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction.Subunit interface residues F129 and H294 of human RAD51 are essential for recombinase function.GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination Visualizing protein-DNA interactions at the single-molecule level Rad51 inhibits translocation formation by non-conservative homologous recombination in Saccharomyces cerevisiae.Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.Single-molecule imaging brings Rad51 nucleoprotein filaments into focus.E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination.Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide.Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses.Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor BRCA2 regulates DMC1-mediated recombination through the BRC repeats.BRCA2: Shining light on the regulation of DNA-binding selectivity by RAD51.

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The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

http://www.wikidata.org/entity/Q24323065

description

2009 nî lūn-bûn

@nan

2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@ast

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@en

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@en-gb

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@nl

type

label

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@ast

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@en

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@en-gb

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@nl

prefLabel

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@ast

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@en

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@en-gb

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

@nl

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J.CELL.2009.02.019

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The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

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Ashok R Venkitaraman

http://www.w3.org/2001/XMLSchema#string

Aura Carreira

http://www.w3.org/2001/XMLSchema#string

Ichiro Amitani

http://www.w3.org/2001/XMLSchema#string

Jovencio Hilario

http://www.w3.org/2001/XMLSchema#string

Mahmud K K Shivji

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Ronald J Baskin

http://www.w3.org/2001/XMLSchema#string

Stephen C Kowalczykowski

http://www.w3.org/2001/XMLSchema#string

P2860

Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control

Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination

Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

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1032-43

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10.1016/J.CELL.2009.02.019

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6

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136

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2009-03-20T00:00:00Z

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19303847

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