Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice
about
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationMSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesAID and Apobec3G haphazard deamination and mutational diversityCharacterization of DNA glycosylase activity by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Attracting AID to targets of somatic hypermutation.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humansRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutationAID-initiated DNA lesions are differentially processed in distinct B cell populations.The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.The AID-induced DNA damage response in chromatin.p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C biasEctopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phaseDoes DNA repair occur during somatic hypermutation?AIDing antibody diversity by error-prone mismatch repair.A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modificationDependence of antibody gene diversification on uracil excision.Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombinationAID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerasesRegulation of AID, the B-cell genome mutator.MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils.Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombinationUracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regionsHuman PMS2 deficiency is associated with impaired immunoglobulin class switch recombinationChanges in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AIDTranscriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase.DNA polymerases in adaptive immunity.Uracil within DNA: an actor of antiviral immunity.The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription.The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.Isolator and other neonatal piglet models in developmental immunology and identification of virulence factors.
P2860
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P2860
Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice
description
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Oktober 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/10/15)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/10/15)
@nl
наукова стаття, опублікована в жовтні 2006
@uk
مقالة علمية (نشرت في 15-10-2006)
@ar
name
Somatic hypermutation and clas ...... )Ung(-/-) double-knockout mice
@ast
Somatic hypermutation and clas ...... )Ung(-/-) double-knockout mice
@en
Somatic hypermutation and clas ...... )Ung(-/-) double-knockout mice
@nl
type
label
Somatic hypermutation and clas ...... )Ung(-/-) double-knockout mice
@ast
Somatic hypermutation and clas ...... )Ung(-/-) double-knockout mice
@en
Somatic hypermutation and clas ...... )Ung(-/-) double-knockout mice
@nl
prefLabel
Somatic hypermutation and clas ...... )Ung(-/-) double-knockout mice
@ast
Somatic hypermutation and clas ...... )Ung(-/-) double-knockout mice
@en
Somatic hypermutation and clas ...... )Ung(-/-) double-knockout mice
@nl
P2093
P921
P1476
Somatic hypermutation and clas ...... )Ung(-/-) double-knockout mice
@en
P2093
Atsushi Tanaka
Dan Nicolae
Grazyna Bozek
Hong Ming Shen
Ursula Storb
P304
P356
10.4049/JIMMUNOL.177.8.5386
P407
P577
2006-10-15T00:00:00Z