Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2
about
Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHLHypoxic regulation of erythropoiesis and iron metabolismHypoxia-inducible factors and the response to hypoxic stressThe VHL tumor suppressor: master regulator of HIFHypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?Regulatory pathways controlling the endovascular invasive trophoblast cell lineageHIF hydroxylase pathways in cardiovascular physiology and medicineHypoxia-mediated regulation of macrophage functions in pathophysiologyInvestigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygenIncreased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null miceAbnormal sympathoadrenal development and systemic hypotension in PHD3-/- miceThe role of PHD2 mutations in the pathogenesis of erythrocytosis.Suppression of vascular network formation by chronic hypoxia and prolyl-hydroxylase 2 (phd2) deficiency during vertebrate development.HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia.HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.Hypoxia-inducible factor 1alpha (HIF1A) mediates distinct steps of rat trophoblast differentiation in gradient oxygen.Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice.Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model.Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies.The placenta: transcriptional, epigenetic, and physiological integration during developmentTargeting iron metabolism in drug discovery and deliveryTumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.Prolyl hydroxylase 2: a novel regulator of β2 -adrenoceptor internalization.Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injuryThe ubiquitin ligase Siah2 and the hypoxia response.Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.The role of oxygen availability in embryonic development and stem cell functionThe function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolismRoles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.Human high-altitude adaptation: forward genetics meets the HIF pathway.Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injuryProlyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal miceOxygen Sensing, Cardiac Ischemia, HIF-1α and Some Emerging ConceptsThe prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen.Vitamin C is dispensable for oxygen sensing in vivoExpression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.
P2860
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P2860
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2
description
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im November 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/11/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/11/01)
@nl
наукова стаття, опублікована в листопаді 2006
@uk
مقالة علمية (نشرت في نوفمبر 2006)
@ar
name
Placental but not heart defect ...... l hydroxylase domain protein 2
@ast
Placental but not heart defect ...... l hydroxylase domain protein 2
@en
Placental but not heart defect ...... l hydroxylase domain protein 2
@nl
type
label
Placental but not heart defect ...... l hydroxylase domain protein 2
@ast
Placental but not heart defect ...... l hydroxylase domain protein 2
@en
Placental but not heart defect ...... l hydroxylase domain protein 2
@nl
prefLabel
Placental but not heart defect ...... l hydroxylase domain protein 2
@ast
Placental but not heart defect ...... l hydroxylase domain protein 2
@en
Placental but not heart defect ...... l hydroxylase domain protein 2
@nl
P2093
P2860
P3181
P356
P1476
Placental but not heart defect ...... l hydroxylase domain protein 2
@en
P2093
Guo-Hua Fong
Hiromi Takeda
Kotaro Takeda
Li-Juan Duan
Vivienne C. Ho
P2860
P304
P3181
P356
10.1128/MCB.00425-06
P407
P50
P577
2006-11-01T00:00:00Z