S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response
about
A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylationRegulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networksIdentification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potentialMdm2 links genotoxic stress and metabolism to p53.Mitochondria are required for pro-ageing features of the senescent phenotype.GLAD4U: deriving and prioritizing gene lists from PubMed literaturePotential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signalingROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells.S6 kinase 2 promotes breast cancer cell survival via Akt.Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells.F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stressA novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells.Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers.IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1mTORC1 and p53: clash of the gods?p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1.A viral kinase mimics S6 kinase to enhance cell proliferation.A new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway predicts clinical outcome of head and neck cancer.ZRF1 is a novel S6 kinase substrate that drives the senescence programme.mTORC1 signaling: what we still don't know.Metabolic regulation by p53.Beyond ATM: the protein kinase landscape of the DNA damage response.Exploiting p70 S6 kinase as a target for ovarian cancer.MDM2's social network.p53 as an intervention target for cancer and aging.Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery.Transcriptional regulation of the stress response by mTOR.Different interactomes for p70-S6K1 and p54-S6K2 revealed by proteomic analysis.mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels.DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1.Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling.P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers.The Many Faces of MDM2 Binding Partners.In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell LinesAdult-onset, short-term dietary restriction reduces cell senescence in mice.Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish.Targeting metabolism and autophagy in the context of haematologic malignanciesOverexpression of RPS6KB1 predicts worse prognosis in primary HCC patients.p57Kip2 is an unrecognized DNA damage response effector molecule that functions in tumor suppression and chemoresistance.Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming.
P2860
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P2860
S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response
description
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im September 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/09/01)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/09/01)
@nl
наукова стаття, опублікована у вересні 2010
@uk
مقالة علمية (نشرت في سبتمبر 2010)
@ar
name
S6K1 is a multifaceted regulat ...... status and DNA damage response
@ast
S6K1 is a multifaceted regulat ...... status and DNA damage response
@en
S6K1 is a multifaceted regulat ...... status and DNA damage response
@nl
type
label
S6K1 is a multifaceted regulat ...... status and DNA damage response
@ast
S6K1 is a multifaceted regulat ...... status and DNA damage response
@en
S6K1 is a multifaceted regulat ...... status and DNA damage response
@nl
prefLabel
S6K1 is a multifaceted regulat ...... status and DNA damage response
@ast
S6K1 is a multifaceted regulat ...... status and DNA damage response
@en
S6K1 is a multifaceted regulat ...... status and DNA damage response
@nl
P2093
P2860
P3181
P356
P1433
P1476
S6K1 is a multifaceted regulat ...... status and DNA damage response
@en
P2093
Chakradhar Velagapudi
David Meek
Deyong Jia
Hongbing Zhang
Huijuan Liu
Jenny Fung Ling Chau
P2860
P304
P3181
P356
10.1038/EMBOJ.2010.166
P407
P50
P577
2010-09-01T00:00:00Z